CAJ | 학술논문

目的以七乙酰-1-α-溴代乳糖为供体,以不同聚合度的缩乙二醇(n=4,5,6)为连接臂合成三个二聚乳糖化合物;以重症烧伤大鼠为模型,研究其体内抗白细胞-内皮细胞粘附活性.结果研究表明与对照组(食盐水)相比,这三个合成的二聚乳糖化合物具有良好的抗休克活性.结论以缩乙二醇为连接臂合成的二聚乳糖化合物具有良好的抗休克活性;聚合度的不同,对抗休克活性有显著影响.
목적 이칠을선-1-α-추대유당위공체,이불동취합도적축을이순(n=4,5,6)위련접비합성삼개이취유당화합물;이중증소상대서위모형,연구기체내항백세포-내피세포점부활성.결과 연구표명여대조조(식염수)상비,저삼개합성적이취유당화합물구유량호적항휴극활성.결론 이축을이순위련접비합성적이취유당화합물구유량호적항휴극활성;취합도적불동,대항휴극활성유현저영향.
Three divalent β-D-galactopyranosyl-(1→4)-β-D-glucopyranosides were synthesized using acetylated lactosyl bromide as donor and polyethylene glycols with different polymeric degree (n= 4, 5, 6) as linker, and evaluated for in vivo inhibitory activity to leukocyte-endothelial cell adhesion on severe burn-shock rats. The result showed that the length of linkers had apparent influence on anti cell adhesion activity.