CAJ | 학술논문

目的：探讨低剂量托吡酯(商品名：妥泰，<200mg）对癫痫发作的疗效。方法：33例癫痫患者采用妥泰单用或联合其他抗癫痫药治疗，起始剂量25mg,qd；另外40例患者采用卡马西平治疗作为对照。结果：妥泰治疗组的有效率（93.9%）明显高于卡马西平治疗组（77.5%),P<0.05；同时单一抗癫痫和联合抗癫痫疗效比较显效率有显著性差异（P<0.05）。结论：妥泰对癫痫发作的疗效优于卡马西平，且妥泰单一用药优于联合用药。
목적：탐토저제량탁필지(상품명：타태，<200mg）대전간발작적료효。방법：33례전간환자채용타태단용혹연합기타항전간약치료，기시제량25mg,qd；령외40례환자채용잡마서평치료작위대조。결과：타태치료조적유효솔（93.9%）명현고우잡마서평치료조（77.5%),P<0.05；동시단일항전간화연합항전간료효비교현효솔유현저성차이（P<0.05）。결론：타태대전간발작적료효우우잡마서평，차타태단일용약우우연합용약。
Objective:To study the efficacy of low dose topiramate(<200mg) in treatment of epilepsy.Methods:73 patients with epilepsy were divided to receive once daily single 25 mg topiramate or in combination with other antiepileptic(n=33),or to receive carbamazapine(n=40) as control.Results:The effective rate of the active group(93.9%) was significantly higher than that of the control group(77.5%,P<0.05) and the distinct effective rate of single topiramate was signicantly better than that of combined topiramate therapy (P<0.05).Conclusion:The efficacy of topiramate in treatment of epilepsy is better than that of other antiepileptics,and the efficacy of single topiramate therapy is better than that of the combined topiramate therapy.