CAJ | 학술논문

目的观察慢性丙型肝炎患者在干扰素抗病毒治疗时，对白细胞介素含量的影响。方法对28例以IFN－a作抗病毒治疗的丙肝患者，采用ELISA法进行血清IL－2、IL－4及IL－12检测。结果三者在治疗前的含量分别为14.06±12.63pg／m1、57.89±61.78pg／m1和230.55±420.56pg／m1。治疗结束(第24周)时IL－2测值不变，IL－4测值下降至30.41±40.73pg／m1，IL－12上升至57.89±61.78pg／m1。随访时(第48周)三者恢复至抗病毒治疗前水平。结论采用外源性IFN－a进行抗病毒治疗时，慢性丙型肝炎患者血清IL－4及IL－12等与T淋巴细胞分化发育相关的细胞因子的含量出现一过性改变，这种变化是外源性IFN调节体内T淋巴细胞分化发育的证据之一。
목적관찰만성병형간염환자재간우소항병독치료시，대백세포개소함량적영향。방법대28례이IFN－a작항병독치료적병간환자，채용ELISA법진행혈청IL－2、IL－4급IL－12검측。결과삼자재치료전적함량분별위14.06±12.63pg／m1、57.89±61.78pg／m1화230.55±420.56pg／m1。치료결속(제24주)시IL－2측치불변，IL－4측치하강지30.41±40.73pg／m1，IL－12상승지57.89±61.78pg／m1。수방시(제48주)삼자회복지항병독치료전수평。결론채용외원성IFN－a진행항병독치료시，만성병형간염환자혈청IL－4급IL－12등여T림파세포분화발육상관적세포인자적함량출현일과성개변，저충변화시외원성IFN조절체내T림파세포분화발육적증거지일。
Objective To study the influence of interferon therapy on some of the interleukin levels in sera in patients with chronic HCV infection.Methods Serum interleukin-2 (IL-2),interleukin-4 (IL-4) and interleukin-12 (IL-12) in a group of patients with HCV infection who underwent interferon treatment were dynamically detected using enzyme linked immunosorbent assay (ELISA).Results The levels of IL-2,IL-4 and IL-12 were 14.06±12.63pg/ml,57.89±61.78pg/ml and 230.55±420.56pg/ml respectively before interferon treatment.By the end of 24 weeks of therapeutic period,the level of IL-12 increased up to 346.92±527.84pg/ml,while the level of IL-4 decresed from 57.89±61.78pg/ml to 30.41±40.73pg/ml.At the following days (at 48th week sinec the therapy had started),all of three interleukins has returned about the same level before anti-virutic treatment.Conclusion During the anti-virus therapy with interferon,there is a transient change for some of interleukins which induced the evolution of T lymphocyte.