CAJ | 학술논문

目的　研究腹腔镜胆囊切除术对机体应　激反应的影响。方法　将70例胆囊炎、胆囊结石患者随机分成腹腔镜胆囊切除组(LC)和开腹胆囊切除组(OC)。术前和术后第1，3，5，7?!d采集外周静脉血，测定白细胞介素1β(IL-1β)，肿瘤坏死因子α(TNF-α)，白细胞介素6(IL-6)和C-反应蛋白(CRP)。结果　两组手术前后IL-1β和TNF-α均无明显差异(P>0.05)，两组间手术前后比较也无明显差异(P>0.05)；两组手术后IL-6第1?!d升至最高，与术前及术后第3，5，7?!d比较有高度显著差异(P<0.01)而术前与术后第3，5，7?!d比较无显著差异(P>0.05)，两组之间比较亦无显著差异(P>0.05)；两组手术后CRP第1，3，5?!d均较术前有明显升高(P<0.05)，以术后第1和第3?!d升高最明显，而两组之间比较无显著差异(P>0.05)。结论　LC对机体应激反应与OC相比没有明显差异。
목적　연구복강경담낭절제술대궤체응　격반응적영향。방법　장70례담낭염、담낭결석환자수궤분성복강경담낭절제조(LC)화개복담낭절제조(OC)。술전화술후제1，3，5，7?!d채집외주정맥혈，측정백세포개소1β(IL-1β)，종류배사인자α(TNF-α)，백세포개소6(IL-6)화C-반응단백(CRP)。결과　량조수술전후IL-1β화TNF-α균무명현차이(P>0.05)，량조간수술전후비교야무명현차이(P>0.05)；량조수술후IL-6제1?!d승지최고，여술전급술후제3，5，7?!d비교유고도현저차이(P<0.01)이술전여술후제3，5，7?!d비교무현저차이(P>0.05)，량조지간비교역무현저차이(P>0.05)；량조수술후CRP제1，3，5?!d균교술전유명현승고(P<0.05)，이술후제1화제3?!d승고최명현， 이량조지간비교무현저차이(P>0.05)。결론　LC대궤체응격반응여OC상비몰유명현차이。
Objective　To investigate the systemic stress responses of laparoscopic cholecystectomy(LC). Methods　Seventy patients with cholecystolithiasis were randomly divided into two groups: LC and open cholecystectomy(OC). Peripheral blood samples were obtained during the preoperative day and 1, 3, 5, 7 day after operation. Serum cytokines levels (TNF-α, IL-1β and IL-6) and C-reactive protein(CRP) were measured. Results　Changes of TNF-α and IL-1β before or after surgery in both groups showed no significant difference(P>0.05). Serum concentrations of IL-6 and CRP after surgery in both groups were significantly higher than those before surgery(P<0.05); but there were no significant difference between the two groups(P>0.05). Conclusions　The systemic stress responses of LC have no significant difference comparing with OC.