CAJ | 학술논문

目的:研究杀虫单(SCD)的中毒机理及二巯基丙磺酸钠(Na-DMPS)对琥珀酸脱氢酶(SDH)的保护作用。方法:小鼠随机分为三组：对照组、SCD 组、(Na-DMPS + SCD)组。观察三组小鼠肝及心肌线粒体琥珀酸脱氢酶(SDH)、血浆乳酸脱氢酶(LDH)活力的变化。结果:与对照组相比，SCD 组SDH活力显著下降(P<0.05)， LDH 明显升高(P<0 .001)；( Na-DMPS + SCD )组SDH活力较SCD组明显升高(P<0.05)，LDH显著降低(P<0.001) 。结论:SCD可抑制线粒体 SDH活力，抑制细胞呼吸。Na-DMPS 可拮抗其抑制作用，这种拮抗作用在防治SCD中毒方面具有重要意义。
목적:연구살충단(SCD)적중독궤리급이구기 병광산납(Na-DMPS)대호박산탈경매(SDH)적보호작용。방법:소서수궤분위삼조：대조조、SCD 조、(Na-DMPS + SCD)조。관찰삼 조소서간급심기선립체호박산탈경매(SDH)、혈장유산탈경매(LDH)활력적변화。결과:여대조조상비，SCD 조SDH활력현저하강(P<0.05)， LDH 명현승고(P<0 .001)；( Na-DMPS + SCD )조SDH활력교SCD조명현승고(P<0.05)，LDH현 저강저(P<0.001) 。결론:SCD가억제선립체 SDH활력，억제세포호흡。Na-DMPS 가길항기억제 작용，저충길항작용재방치SCD중독방면구유중요의의。
Objective：To investigate the mechanism of acute Sodium ammonium dimethyl-2-propano-1.3-dithiosulfate monohydrate(SC D) p oison and the protective antidotal effects of 2.3-Dimercaptopropane-1-sulfona te sodium(Na-DMPS) on Succinate dehydrogenase(SDH) activities in mice.Methods：The mice were randomly divided into three groups: Contr ol group, SCD group, (Na-DMPS) group. The activities of Succinate dehydrogenas e (SDH) in mitochondria of liver and myocardium and Lactic dehydrogenase(LDH) acti vities in plasma of three groups were determined.Results：SDH decreased significantly (P<0.05) an d LDH increased remarkably (P<0.001) in SCD group compared with those of control group. SDH enha nced obviously (P<0.05) and LDH reduced notably (P<0.001) in (Na-DMPS + SCD) group than those of SCD group.Conclusion：SCD could inhibit the activities of SDH of mitochond ria consequently suppressing cell respiration in mice. Na-DMPS could antagonize significantly the inhibiting effects of SCD on the activities of SDH. This ant agonistic actions play an important role in preventing and curing SCD pois on.