CAJ | 학술논문

目的　探讨西安地区食管癌与p53和H-Ras高表达的关系. 方法　应用分子流行病学研究方法，调查分析了西安地区61例病例、43例对照的基础资料并检测组织中p53和H-Ras高表达情况. 结果　病例组p53和H-Ras的高表达率（分别为80.3%, 41.0%）均高于对照组(30.2%, 16.3%, P<0.01). p53高表达的危险因素是H-Ras高表达与肿瘤家族史且二者具有协同作用. 结论　p53和H-Ras高表达是西安地区食管癌重要的生物学标志.
목적　탐토서안지구식관암여p53화H-Ras고표체적관계. 방법　응용분자류행병학연구방법，조사분석료서안지구61례병례、43례대조적기출자료병검측조직중p53화H-Ras고표체정황. 결과　병례조p53화H-Ras적고표체솔（분별위80.3%, 41.0%）균고우대조조(30.2%, 16.3%, P<0.01). p53고표체적위험인소시H-Ras고표체여종류가족사차이자구유협동작용. 결론　p53화H-Ras고표체시서안지구식관암중요적생물학표지.
AIM　To evaluate the over expression of p53 protein and H-Ras in the process of esophageal cancer (EC) in Xi'an city. METHODS　Molecular epidemiological case-control study was carried out to study the risk factor of EC in Xi'an, and 61 cases and 43 control specimens were examined for p53 protein and H-Ras over expression. RESULTS　Over expression of p53 protein and H-Ras of cases (80.3%,41.0% respectively) was significantly higher than relatives of controls (30.2%, 16.3%, P<0.01). Family cancer history and H-Ras over expression were the main risk factors in over expression of p53 protein. CONCLUSION　Over expression of p53 protein and H-Ras is the most important biomarker in the process of esophageal cancer (EC) in Xi'an city.