CAJ | 학술논문

目的:研究云南蕊木中有效成分蕊木宁在大鼠体内的组织分布与排泄.方法:将蕊木宁用放射性元素3H标记,分别以静注和口服方式给予受试大鼠,收集血液、脏器、尿液、胆汁等,用液体闪烁记数仪测量其放射活性.结果:血中的放射活性呈二相衰减,t1/2α为12min,t1/2β 28.1h.口服给药1h后,肝脏中的放射物浓度为277.5±17.8ng/g,肾脏为182.4±12.0ng/g;并且,48h内,大部分放射活性(66%)由尿液排泄,小部分(14%)由胆汁排泄.结论:肝脏可能是蕊木宁的主要靶器官,且蕊木宁自身产生肝肠循环的可能性较小.
목적:연구운남예목중유효성분예목저재대서체내적조직분포여배설.방법:장예목저용방사성원소3H표기,분별이정주화구복방식급여수시대서,수집혈액、장기、뇨액、담즙등,용액체섬삭기수의측량기방사활성.결과:혈중적방사활성정이상쇠감,t1/2α위12min,t1/2β 28.1h.구복급약1h후,간장중적방사물농도위277.5±17.8ng/g,신장위182.4±12.0ng/g;병차,48h내,대부분방사활성(66%)유뇨액배설,소부분(14%)유담즙배설.결론:간장가능시예목저적주요파기관,차예목저자신산생간장순배적가능성교소.
OBJECTIVE: To study the tissue distribution and excretion of 3H Kopsinine 1 in rats. METHODS: HKopsinine 1 were admnistrated to 7 groups of 6 rats orally or intravenously, then blood, organ, urine,feces and bile were collected to prepare sample solutions. After 12 hours, the radioactivity was measured by Liquid Scintillation Counter. RESUTS: The radioactivity time curve can be described by a two compartment model. The T1/2α and the T1/2β is 12 minutes and 28. 1 hours respectively. After oral administration the radioactivity in liver at 1 hour was 277.5± 17.8ng/g and that in Kidney was 182.4±12 0ng/g. The majority (66%) of radioactivity was recovered from urine in 24 hours and 14% of radioactivity was from bile in 48 hours. CONCLUSION: Results suggest that liver is the main effective organ of Kopsinine 1, and also, Kopsinine 1 has a little possibility for enterohepatic circulation.