CAJ | 학술논문

采用高效抗逆转录病毒疗法(HAART)后,由于免疫功能恢复和机会性感染的减少,极大地改变了艾滋病毒(HIV)感染者眼部疾病的病程及病史.然而,即使在HAART时代,眼部并发症仍然是艾滋病的临床特征之一,在发展中国家中尤其如此,而绝大多数HIV阳性病患者生活在发展中国家或地区.由于缺乏检验设备和经验、卫生条件差、微生物环境不同及缺乏有效的治疗,生活在发展中国家和地区的HIV感染者眼部并发症的特征与发达地区的艾滋病患者大不相同.因此,治疗发展中国家和地区HIV感染者的眼部并发症,具有更大的挑战性.此外,成人和儿童艾滋病患者眼部并发症也是不同的.与此同时,HAART的副作用也给眼部并发症带来了新的危险因素.所以,相关的研究应给予更多的关注.
채용고효항역전록병독요법(HAART)후,유우면역공능회복화궤회성감염적감소,겁대지개변료애자병독(HIV)감염자안부질병적병정급병사.연이,즉사재HAART시대,안부병발증잉연시애자병적림상특정지일,재발전중국가중우기여차,이절대다수HIV양성병환자생활재발전중국가혹지구.유우결핍검험설비화경험、위생조건차、미생물배경불동급결핍유효적치료,생활재발전중국가화지구적HIV감염자안부병발증적특정여발체지구적애자병환자대불상동.인차,치료발전중국가화지구HIV감염자적안부병발증,구유경대적도전성.차외,성인화인동애자병환자안부병발증야시불동적.여차동시,HAART적부작용야급안부병발증대래료신적위험인소.소이,상관적연구응급여경다적관주.
The introduction of highly active antiretroviral therapy (HAART) has greatly changed the pattern and natural history of ocular diseases of HIV-infected patients, resulting from the immune recovery and reduction of opportunistic infections. However, ophthalmic complica-tion continues to be concern in AIDS even in the HAART era, especially in developing areas, where absolute majority of HIV-positive patients live. Lack of test facilities and experience, poor conditions of hygiene, different microbiological environment, absence of effective treatment etc., characterize the ophthalmic manifestation of HIV-infected patients in developing countries from that in developed regions and thus pose a great challenge to the ophthalmic treatment in developing area. Not only varied from region to region, ocular complications are distinctive between adults and children. At the same time, the side effects due to the application of HAART pose their own risks of ocular complication and should, therefore, be given more research attention.