国际检验医学杂志
國際檢驗醫學雜誌
국제검험의학잡지
INTERNATIONAL JOURNAL OF LABORATORY MEDICINE
2009年
5期
454-455,458
,共3页
黄志刚%黄琛%洪胡萍%马丹颖%任申霁
黃誌剛%黃琛%洪鬍萍%馬丹穎%任申霽
황지강%황침%홍호평%마단영%임신제
肠球菌属%抗药性%细菌%抗菌药
腸毬菌屬%抗藥性%細菌%抗菌藥
장구균속%항약성%세균%항균약
Enterococcus%Drug resistance,bacterial%Anti-bacterial agents
目的 了解医院肠球菌在临床分布状况及利奈唑胺等抗菌药物对肠球菌的抗菌活性,为临床治疗肠球菌感染合理选择抗菌药物提供指导.方法 对本院各种标本分离获得的肠球菌用VITEK微生物自动鉴定仪进行种的鉴定和药物敏感性试验.用WHOVET5软件对统计结果进行分析.结果 三年共检出706株肠球菌,其中粪肠球菌432株占肠球菌61.2%,屎肠球菌241株占34.1%,鹑鸡肠球菌33株占4.7%.粪肠球菌对呋喃妥因、青霉素、四环素、莫西沙星、左氧氟沙星的耐药率分别为5.8%、22.2%、71.0%、16.7%和23.8%,而屎肠球菌的耐药率除四环素外均高于粪肠球菌.本组试验发现3株耐万古霉素肠球菌,耐药率为0.43%,肠球菌对利奈唑胺的敏感率为.100%.结论 肠球菌属细菌在医院内感染逐年增加,耐药率在不断上升,泛耐株在不断增多,本组试验检出3株耐万古霉素肠球菌(VRE).未发现耐利奈唑胺肠球菌.利奈唑胺是目前治疗泛耐株肠球菌特别是治疗耐万古霉素肠球菌感染的最佳选择,但必须合理使用,同时要密切监测肠球菌的耐药趋势,防止耐药菌株的产生.
目的 瞭解醫院腸毬菌在臨床分佈狀況及利奈唑胺等抗菌藥物對腸毬菌的抗菌活性,為臨床治療腸毬菌感染閤理選擇抗菌藥物提供指導.方法 對本院各種標本分離穫得的腸毬菌用VITEK微生物自動鑒定儀進行種的鑒定和藥物敏感性試驗.用WHOVET5軟件對統計結果進行分析.結果 三年共檢齣706株腸毬菌,其中糞腸毬菌432株佔腸毬菌61.2%,屎腸毬菌241株佔34.1%,鶉鷄腸毬菌33株佔4.7%.糞腸毬菌對呋喃妥因、青黴素、四環素、莫西沙星、左氧氟沙星的耐藥率分彆為5.8%、22.2%、71.0%、16.7%和23.8%,而屎腸毬菌的耐藥率除四環素外均高于糞腸毬菌.本組試驗髮現3株耐萬古黴素腸毬菌,耐藥率為0.43%,腸毬菌對利奈唑胺的敏感率為.100%.結論 腸毬菌屬細菌在醫院內感染逐年增加,耐藥率在不斷上升,汎耐株在不斷增多,本組試驗檢齣3株耐萬古黴素腸毬菌(VRE).未髮現耐利奈唑胺腸毬菌.利奈唑胺是目前治療汎耐株腸毬菌特彆是治療耐萬古黴素腸毬菌感染的最佳選擇,但必鬚閤理使用,同時要密切鑑測腸毬菌的耐藥趨勢,防止耐藥菌株的產生.
목적 료해의원장구균재림상분포상황급리내서알등항균약물대장구균적항균활성,위림상치료장구균감염합리선택항균약물제공지도.방법 대본원각충표본분리획득적장구균용VITEK미생물자동감정의진행충적감정화약물민감성시험.용WHOVET5연건대통계결과진행분석.결과 삼년공검출706주장구균,기중분장구균432주점장구균61.2%,시장구균241주점34.1%,순계장구균33주점4.7%.분장구균대부남타인、청매소、사배소、막서사성、좌양불사성적내약솔분별위5.8%、22.2%、71.0%、16.7%화23.8%,이시장구균적내약솔제사배소외균고우분장구균.본조시험발현3주내만고매소장구균,내약솔위0.43%,장구균대리내서알적민감솔위.100%.결론 장구균속세균재의원내감염축년증가,내약솔재불단상승,범내주재불단증다,본조시험검출3주내만고매소장구균(VRE).미발현내리내서알장구균.리내서알시목전치료범내주장구균특별시치료내만고매소장구균감염적최가선택,단필수합리사용,동시요밀절감측장구균적내약추세,방지내약균주적산생.
Objective To investigate the clinical distribution of enterococci and their drug resist-ance to antibacterials (e. g. linezolid), so as to provide guidance to use antibiotics rationally in clinical therapy. Methods VITEK automatic microbial identification system was applied to performing species identification and drug susceptibility test upon the enterococci isolated from various clinical samples in our hospital from Jan 2005 to Dec 2007. WHONET5 software was adopted to perform statistical analy-sis on the test results. Results In the three years,706 strains of enterococci were isolated,in which 432 strains (61.2%) were Enterococeus faecalis, 241 strains (34.10%) were Enterococcus faecium, and 33 strains (4.7%) were Enterococcus gallinarum. The resistance rates of Enterococcus faecalis to nitro-furantoin,penicillin,tetraeycline, moxifloxacin, and levofloxacin were 5.8%, 22.2%, 71.0%, 16.7% and 23.8% respectively. And the resistance rates of Enterococeus faeeium were higher than those of Enteroeoccus faecalis to most antibiotics except tetraeyeline. In this study, 3 strains (0.43%) of vanco-mycin-resistant Enteroeocci were found, while the sensitivity rate of enterococci to linezolid accounted for 100%. Conclusion Enterococcus infection in hospitals is increasing year by year; the resistance rate of enterococci keeps on rising, and the pan-resistant strains are gadually increasing. In this study, 3 strains of vaneomycin-resistant Enterocoeci were found, while no linezolid-resistant enterococci strain was isolated. Linezolid is optimal antibiotic to treat pan-resistant Enteroeoeeus infection especially the infection of vancomyein-resistant enterococci. However, its use must be reasonable so as to avoid the production of resistant strains.
