中国临床药理学杂志
中國臨床藥理學雜誌
중국림상약이학잡지
THE CHINESE JOURNAL OF CLINICAL PHARMACOLOGY
2009年
4期
298-301
,共4页
洪艳艳%陈振东%张明军%俞敏%吴秀伟%叶瑞萍%刘利炜%杨扬
洪豔豔%陳振東%張明軍%俞敏%吳秀偉%葉瑞萍%劉利煒%楊颺
홍염염%진진동%장명군%유민%오수위%협서평%류리위%양양
氟尿嘧啶缓释制剂%药代动力学%恶性胸腔积液%恶性腹腔积液
氟尿嘧啶緩釋製劑%藥代動力學%噁性胸腔積液%噁性腹腔積液
불뇨밀정완석제제%약대동역학%악성흉강적액%악성복강적액
fluorouracil sustained release preparations%pharmacokinet-its%malignant pleural effusions%malignant ascites
目的 研究氟尿嘧啶(5-Fu,抗癌药)植入剂治疗恶性胸腹水的药代动力学特点.方法 入组12例恶性胸腹水患者,胸腹腔内植入氟尿嘧啶植入剂1500 mg,定时取胸腹水及外周血样,高效液相色谱法测定5-Fu浓度,计算药代动力学参数.结果 胸腹水药物浓度高,血药浓度低,2者比较差异显著(P<0.05).在胸腹水中,药物浓度下降很慢,15天左右仍可维持有效浓度.结论 氟尿嘧啶植入剂腔内植入后,局部药物浓度高,作用时间长.
目的 研究氟尿嘧啶(5-Fu,抗癌藥)植入劑治療噁性胸腹水的藥代動力學特點.方法 入組12例噁性胸腹水患者,胸腹腔內植入氟尿嘧啶植入劑1500 mg,定時取胸腹水及外週血樣,高效液相色譜法測定5-Fu濃度,計算藥代動力學參數.結果 胸腹水藥物濃度高,血藥濃度低,2者比較差異顯著(P<0.05).在胸腹水中,藥物濃度下降很慢,15天左右仍可維持有效濃度.結論 氟尿嘧啶植入劑腔內植入後,跼部藥物濃度高,作用時間長.
목적 연구불뇨밀정(5-Fu,항암약)식입제치료악성흉복수적약대동역학특점.방법 입조12례악성흉복수환자,흉복강내식입불뇨밀정식입제1500 mg,정시취흉복수급외주혈양,고효액상색보법측정5-Fu농도,계산약대동역학삼수.결과 흉복수약물농도고,혈약농도저,2자비교차이현저(P<0.05).재흉복수중,약물농도하강흔만,15천좌우잉가유지유효농도.결론 불뇨밀정식입제강내식입후,국부약물농도고,작용시간장.
Objective To investigate the pharmacokinetics of fluoroura-cil (5-Fu) sustained release implant (FSRI) administered intrapleural-ly or intraperitoneally in the patients with malignant pleural effusions or ascites. Methods Twelve patients with moderate or large malignant pleural effusions or ascites were enrolled. FSRI was administered intra-pleurally or intraperitoneally at a fixed dosage of 1500 mg. The pleural or peritoneal effusions and plasma samples were obtained before and after administration. Concentrations of 5-Fu were measured by HPLC. Phar-macokinetic parameters were calculated. Results In the pleural(perito-neal) effusions, 5-Fu concentration was significantly higher than that in plasma (P<0.05 ). Drugs released slowly, and the concentrations in the effusions were still more than the effective concentration at the 15th day.Conclusion When administered intrapleurally or intraperitoneally flu-orouracil sustained release implant had a long elimination and high localconcentrations.
