CAJ | 학술논문

目的探讨不同剂量的顺式阿曲库铵应用于小儿腹腔镜下手术的药效学特点.方法择期行腹腔镜下手术的小儿80例,随机分成2组,分别静注2 ED95 (Ⅰ组)或3 ED95 (Ⅱ组)的顺式阿曲库铵,记录两组肌松阻滞时效并对插管条件进行评级,观察阻滞起效时间、TOF无反应期、阻滞维持时间、肌松恢复指数与体内作用时间.结果 Ⅱ组气管插管时肌松阻滞和插管条件较Ⅰ组好;肌松起效时间Ⅱ组较Ⅰ组短;TOF无反应期、阻滞维持时间和体内作用时间两组比较均有显著性差异;两组肌松恢复指数无显著差异.结论 3ED95诱导剂量顺式阿曲库铵应用于小儿起效快且插管条件佳,且TOF无反应期、阻滞维持时间和体内作用时间均较2ED95剂量顺式阿曲库铵的时间长;两组恢复指数无明显差异.
목적 탐토불동제량적순식아곡고안응용우소인복강경하수술적약효학특점.방법 택기행복강경하수술적소인80례,수궤분성2조,분별정주2 ED95 (Ⅰ조)혹3 ED95 (Ⅱ조)적순식아곡고안,기록량조기송조체시효병대삽관조건진행평급,관찰조체기효시간、TOF무반응기、조체유지시간、기송회복지수여체내작용시간.결과 Ⅱ조기관삽관시기송조체화삽관조건교Ⅰ조호;기송기효시간Ⅱ조교Ⅰ조단;TOF무반응기、조체유지시간화체내작용시간량조비교균유현저성차이;량조기송회복지수무현저차이.결론 3ED95유도제량순식아곡고안응용우소인기효쾌차삽관조건가,차TOF무반응기、조체유지시간화체내작용시간균교2ED95제량순식아곡고안적시간장;량조회복지수무명현차이.
Objective To observe the pharmacodynamic characteristics of different doses of cis-atracurium used in laparoscopic surgery on children.Methods 80 cases of selective laparoscopic surgery on children were randomly divided into 2 groups, 2 ED95 (Ⅰ group) or 3 ED95 (Ⅱ group) of cis-atracurium were intravenously given respectively.Record two group's muscle block time-effect and intubation conditions to observe the onset time of block, TOF-free response period, duration of anesthesia, muscle relaxation index and time in vivo recovery.Results Tracheal intubation in group Ⅱ with muscle relaxant block and intubation conditions better than groupⅠ;onset time of muscle relaxation in group Ⅱshorter than that in groupⅠ;TOF non-response period, maintain time of block and the time of function in vivo of two groups were different significantly;muscle recovery index were not significantly different Conclusion 3ED95 inducing dose of cis-atracurium effect on children with fast and excellent intubation conditions, and no response to TOF period and maintain time of block and the time of function in vivo longer than 2ED95 dose cis-atracurium;two groups had no significant difference in recovery index.