中华口腔医学杂志
中華口腔醫學雜誌
중화구강의학잡지
Chinese Journal of Stomatology
2009年
6期
327-331
,共5页
白斑,口腔%口腔肿瘤%危险因素%回顾性研究
白斑,口腔%口腔腫瘤%危險因素%迴顧性研究
백반,구강%구강종류%위험인소%회고성연구
Leukoplakia,oral%Mouth neoplasms%Risk factors%Retrospective studies
目的 通过对409例口腔黏膜白斑患者的回顾性综合分析,探讨口腔黏膜白斑癌变的相关危险因素.方法 首先进行单因素检验,观察性别、年龄、病程、系统疾病、吸烟、饮酒、病变部位、临床类型、病变数量、病变范围、症状与口腔黏膜白斑组织病理的关系,筛选与口腔黏膜白斑组织病理相关的变量,进入多元Logistic回归分析模型,计算这些因素的相对危险度(OR值)及95%可信区间.结果 409例口腔黏膜白斑中52例(包括9例重度异常增生)发生了癌变,癌变率为12.7%.其中,性别、年龄、临床分型、病变部位和症状被选入多元Logistic回归分析模型.多元Logistic回归分析结果表明:与单纯增生相比,发生轻中度异常增生的危险性,女性口腔黏膜白斑患者是男性的2.40倍,颗粒型口腔黏膜白斑是均质型的2.81倍,危险区是非危险区的1.98倍,伴有症状的口腔黏膜白斑是无症状的1.84倍.发生重度异常增生及癌变的危险性,女性患者是男性患者的3.11倍,颗粒型、溃疡型、疣状型口腔黏膜白斑分别是均质型的4.50、5.63、4.09倍,危险区是非危险区的2.79倍,伴有症状的口腔黏膜白斑是无症状的4.38倍.结论 口腔黏膜白斑癌变与性别、年龄、临床类型、病变部位及症状等相关.
目的 通過對409例口腔黏膜白斑患者的迴顧性綜閤分析,探討口腔黏膜白斑癌變的相關危險因素.方法 首先進行單因素檢驗,觀察性彆、年齡、病程、繫統疾病、吸煙、飲酒、病變部位、臨床類型、病變數量、病變範圍、癥狀與口腔黏膜白斑組織病理的關繫,篩選與口腔黏膜白斑組織病理相關的變量,進入多元Logistic迴歸分析模型,計算這些因素的相對危險度(OR值)及95%可信區間.結果 409例口腔黏膜白斑中52例(包括9例重度異常增生)髮生瞭癌變,癌變率為12.7%.其中,性彆、年齡、臨床分型、病變部位和癥狀被選入多元Logistic迴歸分析模型.多元Logistic迴歸分析結果錶明:與單純增生相比,髮生輕中度異常增生的危險性,女性口腔黏膜白斑患者是男性的2.40倍,顆粒型口腔黏膜白斑是均質型的2.81倍,危險區是非危險區的1.98倍,伴有癥狀的口腔黏膜白斑是無癥狀的1.84倍.髮生重度異常增生及癌變的危險性,女性患者是男性患者的3.11倍,顆粒型、潰瘍型、疣狀型口腔黏膜白斑分彆是均質型的4.50、5.63、4.09倍,危險區是非危險區的2.79倍,伴有癥狀的口腔黏膜白斑是無癥狀的4.38倍.結論 口腔黏膜白斑癌變與性彆、年齡、臨床類型、病變部位及癥狀等相關.
목적 통과대409례구강점막백반환자적회고성종합분석,탐토구강점막백반암변적상관위험인소.방법 수선진행단인소검험,관찰성별、년령、병정、계통질병、흡연、음주、병변부위、림상류형、병변수량、병변범위、증상여구강점막백반조직병리적관계,사선여구강점막백반조직병리상관적변량,진입다원Logistic회귀분석모형,계산저사인소적상대위험도(OR치)급95%가신구간.결과 409례구강점막백반중52례(포괄9례중도이상증생)발생료암변,암변솔위12.7%.기중,성별、년령、림상분형、병변부위화증상피선입다원Logistic회귀분석모형.다원Logistic회귀분석결과표명:여단순증생상비,발생경중도이상증생적위험성,녀성구강점막백반환자시남성적2.40배,과립형구강점막백반시균질형적2.81배,위험구시비위험구적1.98배,반유증상적구강점막백반시무증상적1.84배.발생중도이상증생급암변적위험성,녀성환자시남성환자적3.11배,과립형、궤양형、우상형구강점막백반분별시균질형적4.50、5.63、4.09배,위험구시비위험구적2.79배,반유증상적구강점막백반시무증상적4.38배.결론 구강점막백반암변여성별、년령、림상류형、병변부위급증상등상관.
Objective To investigate the risk factors for malignant transformation of oral leukoplakia. Methods A total of 409 cases with oral leukoplakia was retrospectively analyzed. Single factor test was first performed to examine the associations between oral leukoplakia's histopathological classification and each of risk factors including sex, age, systemic diseases, course of disease, clinical classification,site, size, numbers of lesion, alcohol and tobacco consumption, and symptom. Then the association of these selected factors with oral leukoplakia's histopathological classification was evaluated using multiple logistic regression analysis. Results Fifty-two cases of all 409 patients with oral leukoplakia (including 9 severe dysplasia) developed oral cancer. The ratio of malignant transformation was 12.7%. Sex, age, clinical type, site and symptom were chosen as risk factors incorporated into the multiple logistic regression models.The risk of mild-moderate dysplasia in female was 2. 40 times as high as that in male. The risk of mild-moderate dysplasia of speckled leukoplakia was 2. 81 times as high as that of homogeneous leukoplakia. The risk of mild-moderate dysplasia of dangerous site was 1. 98 times as high as that non-dangerous site. The risk of mild-moderate dysplasia with symptom was 1. 84 times as high as that without symptom. The risk of severe dysplasia and oral cancer in female was 3. 11 times as high as that in male. The risk of severe dysplasia and oral cancer of speckled (4. 50 times), ulcerative (5. 63 times), verrucous leukoplakia (4.09 times) were much higher than that of homogeneous leukoplakia. The risk of severe dysplasia and oral cancer in dangerous site was 2. 79 times as high as in non-dangerous site. The risk of severe dysplasia and oral cancer in leukoplakia with symptom was 4. 38 times as high as without symptom. Conclusions The malignant transformation of oral leukoplakia is correlated to sex, clinical type, site and symptom.
