中华流行病学杂志
中華流行病學雜誌
중화류행병학잡지
CHINESE JOURNAL OF EPIDEMIOLOGY
2010年
9期
983-987
,共5页
江朝强%徐琳%林洁明%林大庆%张维森%刘斌%靳雅丽%郑家强%Thomas G.Neil
江朝彊%徐琳%林潔明%林大慶%張維森%劉斌%靳雅麗%鄭傢彊%Thomas G.Neil
강조강%서림%림길명%림대경%장유삼%류빈%근아려%정가강%Thomas G.Neil
吸烟%颈动脉粥样硬化%剂量-反应关系%中老年人
吸煙%頸動脈粥樣硬化%劑量-反應關繫%中老年人
흡연%경동맥죽양경화%제량-반응관계%중노년인
Smoking%Carotid atherosclerosis%Dose-response relationship%Older people
目的 探讨男性中老年人吸烟状况与颈动脉粥样硬化的剂量-反应关系.方法 从<广州生物库队列研究--心血管疾病亚队列>中随机抽取959名≥50岁相对健康的男性中老年人的个人资料与病史、体格检查(包括检测空腹血糖、血脂和血压)及应用彩色多普勒超声测量颈总动脉中-内膜厚度(IMT)及斑块形成.结果 (1)不吸烟者占39.1%、已戒烟者为25.7%和现在吸烟者为35.2%.受检者的平均颈动脉中-内膜厚度为0.78(95%CI:0.77～0.79)mm.其中18.4%受检者单侧或双侧颈动脉中-内膜厚度≥1.0 mm,34.1%的受检者检出颈动脉斑块.(2)在调整年龄、教育、体力活动、体重指数、空腹血糖、甘油三酯、高密度脂蛋白胆固醇、SBP和DBP等混杂因素后,现在吸烟者较从不吸烟者,颈动脉内膜增厚和斑块形成的危险明显增加(OR=1.82,95%CI:1.30～2.55和OR=1.95,95%CI:1.38～2.75,P值均＜0.001);颈动脉IMT和斑块形成的危险随每日吸烟量(支/日)、吸烟时间(年)和吸烟总量(包·年)的增加而明显增加(趋势检验P值均≤0.01).结论 广州市中老年男性人群中吸烟显著增加颈动脉粥样硬化的危险,且存在明显的剂量-反应关系.
目的 探討男性中老年人吸煙狀況與頸動脈粥樣硬化的劑量-反應關繫.方法 從<廣州生物庫隊列研究--心血管疾病亞隊列>中隨機抽取959名≥50歲相對健康的男性中老年人的箇人資料與病史、體格檢查(包括檢測空腹血糖、血脂和血壓)及應用綵色多普勒超聲測量頸總動脈中-內膜厚度(IMT)及斑塊形成.結果 (1)不吸煙者佔39.1%、已戒煙者為25.7%和現在吸煙者為35.2%.受檢者的平均頸動脈中-內膜厚度為0.78(95%CI:0.77～0.79)mm.其中18.4%受檢者單側或雙側頸動脈中-內膜厚度≥1.0 mm,34.1%的受檢者檢齣頸動脈斑塊.(2)在調整年齡、教育、體力活動、體重指數、空腹血糖、甘油三酯、高密度脂蛋白膽固醇、SBP和DBP等混雜因素後,現在吸煙者較從不吸煙者,頸動脈內膜增厚和斑塊形成的危險明顯增加(OR=1.82,95%CI:1.30～2.55和OR=1.95,95%CI:1.38～2.75,P值均＜0.001);頸動脈IMT和斑塊形成的危險隨每日吸煙量(支/日)、吸煙時間(年)和吸煙總量(包·年)的增加而明顯增加(趨勢檢驗P值均≤0.01).結論 廣州市中老年男性人群中吸煙顯著增加頸動脈粥樣硬化的危險,且存在明顯的劑量-反應關繫.
목적 탐토남성중노년인흡연상황여경동맥죽양경화적제량-반응관계.방법 종<엄주생물고대렬연구--심혈관질병아대렬>중수궤추취959명≥50세상대건강적남성중노년인적개인자료여병사、체격검사(포괄검측공복혈당、혈지화혈압)급응용채색다보륵초성측량경총동맥중-내막후도(IMT)급반괴형성.결과 (1)불흡연자점39.1%、이계연자위25.7%화현재흡연자위35.2%.수검자적평균경동맥중-내막후도위0.78(95%CI:0.77～0.79)mm.기중18.4%수검자단측혹쌍측경동맥중-내막후도≥1.0 mm,34.1%적수검자검출경동맥반괴.(2)재조정년령、교육、체력활동、체중지수、공복혈당、감유삼지、고밀도지단백담고순、SBP화DBP등혼잡인소후,현재흡연자교종불흡연자,경동맥내막증후화반괴형성적위험명현증가(OR=1.82,95%CI:1.30～2.55화OR=1.95,95%CI:1.38～2.75,P치균＜0.001);경동맥IMT화반괴형성적위험수매일흡연량(지/일)、흡연시간(년)화흡연총량(포·년)적증가이명현증가(추세검험P치균≤0.01).결론 엄주시중노년남성인군중흡연현저증가경동맥죽양경화적위험,차존재명현적제량-반응관계.
Objective To examine the dose-response relationship of smoking status with carotid atherosclerosis in 959 relatively healthy Chinese men. Methods 959 older Chinese men were selected from Guangzhou Biobank Cohort Study (GBCS) on cardiovascular disease. Personal histories were collected and fasting plasma glucose and lipids, blood pressure, and common carotid artery intima-median thickness (CCA-IMT) were measured. Results ( 1 ) Composition of the cases:39.1% were non-smokers, 25.7% were former smokers and 35.2% were current smokers. The mean (95% confidence interval) carotid IMT was 0.78 (0.77-0.79) mm. 18.4% of the subjects had carotid IMT equal to or thicker than 1.0 mm while 34.1% had carotid plaque. (2)After adjusting for age, sex,physical activity, body mass index, fasting glucose, triglyceride, high-density lipoprotein cholesterol,systolic and diastolic blood pressure, compared to never smokers, current smokers had significantly increased risk for thicker IMT and carotid plaque [odds ratio (OR) = 1.82, 95% GI: 1.30-2.55 and OR=1.95, 95%CI: 1.38-2.75, respectively, all P＜0.001]. The risk for thicker IMT and carotid plaque increased with the increasing amount (cigarettes/day) and duration of smoking (years) as well with cigarette pack-years (P for trend all ≤0.01 ). Conclusion An elevated risk with a clear doseresponse relationship was found between cigarette smoking and carotid atherosclerosis. Quitting smoking or reducing the amount of smoking may lower the risk of atherosclerosis, preventing and controlling the occurrence of cardiovascular diseases, and reducing the related cardiovascular mortalities.
