CAJ | 학술논문

目的观察叶黄素治疗准分子激光原位角膜磨镶术(IASIK)后视疲劳的临床疗效.方法前瞻性病例对照研究选取70例LASIK术后患者,采用隧机数字表法将患者分成治疗组和对照组,除术后常规用药外,治疗组加用叶黄索口服、观察患者术后1周、1个月和3个月的视力、屈光度、调节幅度、调节滞后、调节灵敏度、正E负相对节以及对比敏感度,并对患者视疲劳情况进行评分.采用卡方检验和独立样本t检验结果治疗组术后1周、1个月和3个月患者视疲劳评分总分均低于对照组,差异有统计学意义0=2.77、2.17、9.09,P＜0.05).术后3个月,治疗组的调节幅度和调节滞后量与对照组相比,差异有统计学意义(t=2.35、2.57、P＜0.05),调节灵敏度和正负相对调节在各随访时间点两组的差异无统计学意义术后1个月,眩光和无眩光环境下,在1.7、2.6、6.6 c/d的空间频率,治疗组对比敏感度高于对照组,差异均有统计学意义(眩光环境t=3.68、2.84、2.45,无眩光环境t=2.15、2.60、3.09,P＜0.05).术后3个月,眩光环境下,在1.0、2.6、4.2、10.4 c/d的空间频率,治疗组的对比敏感度高于对照组,差异有统计学意(t=3.47、5.64、4.56、4.10,P＜0.05)；无眩光状态下,治疗组在各空间频率的对比敏感度均高于对照组(t=2.16、2.31、3.51、5.56、5.00、4.62,P＜0.05) 结论叶黄索能够有效缓解LASIK术后视疲劳症状,改善对比敏感度.
목적 관찰협황소치료준분자격광원위각막마양술(IASIK)후시피로적림상료효.방법 전첨성병례대조연구 선취70례LASIK술후환자,채용수궤수자표법장환자분성치료조화대조조,제술후상규용약외,치료조가용협황색구복、관찰환자술후1주、1개월화3개월적시력、굴광도、조절폭도、조절체후、조절령민도、정E부상대절이급대비민감도,병대환자시피로정황진행평분.채용잡방검험화독립양본t검험 결과 치료조술후1주、1개월화3개월환자시피로평분총분균저우대조조,차이유통계학의의0=2.77、2.17、9.09,P＜0.05).술후3개월,치료조적조절폭도화조절체후량여대조조상비,차이유통계학의의(t=2.35、2.57、P＜0.05),조절령민도화정부상대조절재각수방시간점량조적차이무통계학의의술후1개월,현광화무현광배경하,재1.7、2.6、6.6 c/d적공간빈솔,치료조대비민감도고우대조조,차이균유통계학의의(현광배경t=3.68、2.84、2.45,무현광배경t=2.15、2.60、3.09,P＜0.05).술후3개월,현광배경하,재1.0、2.6、4.2、10.4 c/d적공간빈솔,치료조적대비민감도고우대조조,차이유통계학의(t=3.47、5.64、4.56、4.10,P＜0.05)；무현광상태하,치료조재각공간빈솔적대비민감도균고우대조조(t=2.16、2.31、3.51、5.56、5.00、4.62,P＜0.05) 결론 협황색능구유효완해LASIK술후시피로증상,개선대비민감도.
Objective To observe the effects of lutein on asthenopia after laser in situ keratomileusis (LASIK).Methods It was a prospocttve case control study.A total of 70 patients who had undergone LASIK were divided into treatment and control groups romdomly.The treatment group was treated with lutein in addition to conventional postoperative medication.Visual acuity,refractive error (RE),amplitude of accommodation,accommodative lag,accommodative facility,positive and negative relative accommodation,contrast sensitivity (CS) and asthenopia scores were measured at I week,I month and 3 months after LASIK surgery.Data were analyzed using chi-~square test and independent sample t test.Results The asthenopia score for the treatment group was lower than the score for the control group at 1 week,1 month and 3 months after LASIK surgery.The difference was significant (t=2.77,2.17,9.09,P＜0.05).There were significant differences in amplitude of accommodation and accommodative lag between the two groups at 3 months after LASIK surgery (t=2.35,2.57,P＜0.05).The differences in positive and negative relative accommodation and accommodative facility were not significant.The CS with or without glare was higher in the treatment group than in the control group at spatial frequencies of 1.7,2.6,6.6 c/d at I month after surgery.The differences were significant (with glare,t=3.68,2.84,2.45; without glare,t=2.15,2.60,3.09,P＜0.05).At 3 months after IASIK.Ihere were significant differences between the two groups in CS (with glare) at spatial frequencies of 1.0,2.6,4.2,10.4 c/d (t=3.47,5.64,4.56,4.10,P＜0.05).Compared to the control group,the CS without glare for the treatment group was higher at every spatial frequency at 3 months after LASIK.The differences were significant (t=2.16,2.31,3.51,5.56,5.00,4.62,P＜0.05).Conclusion Lutein can relieve Ihe symptoms and signs of asthenopia safely and effectively after LASIK.Aud it also can improve the CS of patients.