中华内分泌代谢杂志
中華內分泌代謝雜誌
중화내분비대사잡지
CHINESE JOURNAL OF ENDOCRINOLOGY AND METABOLISM
2010年
5期
351-354
,共4页
晏群%洪洁%顾卫琼%张翼飞%张豫文%石娟%王卫庆%李小英%宁光
晏群%洪潔%顧衛瓊%張翼飛%張豫文%石娟%王衛慶%李小英%寧光
안군%홍길%고위경%장익비%장예문%석연%왕위경%리소영%저광
多囊卵巢综合征%代谢综合征%肥胖症%胰岛素抵抗
多囊卵巢綜閤徵%代謝綜閤徵%肥胖癥%胰島素牴抗
다낭란소종합정%대사종합정%비반증%이도소저항
Polycystic ovary syndrome%Metabolic syndrome%Obesity%Insulin resistance
目的 研究多囊卵巢综合征(PCOS)患者代谢综合征(MS)患病率,并探讨MS发生的危险因素.方法 比较348例年轻的PCOS患者及113名非PCOS正常女性的MS及其组分的患病率.结果 PCOS组MS的患病率为27.0%,明显高于正常对照组的10.6%(P<0.01),除甘油三酯外,其他MS组分在PCOS组均高于正常对照组(P<0.05或P<0.01),但校正年龄和体重指数(BMI)后,差异就不存在统计学意义(P=0.737).分层分析也显示PCOS非肥胖组和肥胖组的MS患病率与相应的正常对照组均无明显差异(均P>0.05).多元逐步回归分析显示稳态模型评估的胰岛素抵抗指数(HOMA-IR)和BMI是MS的独立预测因素(均P<0.01).结论 肥胖和胰岛素抵抗是MS的独立危险因素,PCOS单独并不增加MS的发生风险.
目的 研究多囊卵巢綜閤徵(PCOS)患者代謝綜閤徵(MS)患病率,併探討MS髮生的危險因素.方法 比較348例年輕的PCOS患者及113名非PCOS正常女性的MS及其組分的患病率.結果 PCOS組MS的患病率為27.0%,明顯高于正常對照組的10.6%(P<0.01),除甘油三酯外,其他MS組分在PCOS組均高于正常對照組(P<0.05或P<0.01),但校正年齡和體重指數(BMI)後,差異就不存在統計學意義(P=0.737).分層分析也顯示PCOS非肥胖組和肥胖組的MS患病率與相應的正常對照組均無明顯差異(均P>0.05).多元逐步迴歸分析顯示穩態模型評估的胰島素牴抗指數(HOMA-IR)和BMI是MS的獨立預測因素(均P<0.01).結論 肥胖和胰島素牴抗是MS的獨立危險因素,PCOS單獨併不增加MS的髮生風險.
목적 연구다낭란소종합정(PCOS)환자대사종합정(MS)환병솔,병탐토MS발생적위험인소.방법 비교348례년경적PCOS환자급113명비PCOS정상녀성적MS급기조분적환병솔.결과 PCOS조MS적환병솔위27.0%,명현고우정상대조조적10.6%(P<0.01),제감유삼지외,기타MS조분재PCOS조균고우정상대조조(P<0.05혹P<0.01),단교정년령화체중지수(BMI)후,차이취불존재통계학의의(P=0.737).분층분석야현시PCOS비비반조화비반조적MS환병솔여상응적정상대조조균무명현차이(균P>0.05).다원축보회귀분석현시은태모형평고적이도소저항지수(HOMA-IR)화BMI시MS적독립예측인소(균P<0.01).결론 비반화이도소저항시MS적독립위험인소,PCOS단독병불증가MS적발생풍험.
Objective To study the prevalence of metabolic syndrome (MS) in women with polycystic ovary syndrome (PCOS) ,and to explore the risk factors of MS in young women. Methods The prevalence of MS and its components were evaluated in 348 young women with PCOS and 113 control subjects without PCOS. Results According to the 2005 modified Adult Treatment Panel Ⅲ criteria,MS was found in 27.0% of PCOS women,being significantly higher than 10.6% in the controls(P<0.01). The rates of MS components,except for the triglyceride (TG) level, were all significantly higher in PCOS subjects than those in control subjects ( P < 0. 05 or P < 0.01). However, the difference disappeared after adjustment for age and body mass index ( BMI, P>0. 05). The results of logistic regression analysis revealed that homeostasis model assessment insulin resistance (HOMA-IR)and BMI were the independent predictors of MS( both P<0.01) ,and the presence of PCOS was not the independent risk factor for MS (P>0. 05). Conclusions Obesity and insulin resistance are the independent predictors of MS. PCOS alone does not increase the risk of MS prevalence.
