中国实用医刊
中國實用醫刊
중국실용의간
CENTRAL PLAINS MEDICAL JOURNAL
2012年
16期
8-9
,共2页
结肠肿瘤%Survivin%基质金属蛋白酶-9%血管内皮生长因子
結腸腫瘤%Survivin%基質金屬蛋白酶-9%血管內皮生長因子
결장종류%Survivin%기질금속단백매-9%혈관내피생장인자
Colonic carcinoma%Survivin%Matrix metalloproteinase-9%Vascular endothelial growth factor
目的 探讨Survivin、基质金属蛋白酶-9(MMP-9)和血管内皮生长因子(VEGF)在结肠癌组织中的表达及其与肿瘤进表的关系.方法 采用免疫组化SP法检测60例结肠癌组织中Survivin、MMP-9和VEGF表达情况,并以25例正常结肠组织作为对照.结果 结肠癌组织中Survivin、MMP-9和VEGF表达显著高于正常结肠组织(P＜0.05).结肠癌患者中Ⅲ～Ⅳ期、淋巴结转移患者的Survivin、MMP-9和VEGF阳性表达率分别高于Ⅰ～Ⅱ期和无淋巴结转移患者(P＜0.05).结论 结肠癌组织中Survivin、MMP-9和VEGF的表达水平明显升高,在结肠癌的浸润转移中起到了重要的作用,可作为反映结肠癌进展的生物学指标.
目的 探討Survivin、基質金屬蛋白酶-9(MMP-9)和血管內皮生長因子(VEGF)在結腸癌組織中的錶達及其與腫瘤進錶的關繫.方法 採用免疫組化SP法檢測60例結腸癌組織中Survivin、MMP-9和VEGF錶達情況,併以25例正常結腸組織作為對照.結果 結腸癌組織中Survivin、MMP-9和VEGF錶達顯著高于正常結腸組織(P＜0.05).結腸癌患者中Ⅲ～Ⅳ期、淋巴結轉移患者的Survivin、MMP-9和VEGF暘性錶達率分彆高于Ⅰ～Ⅱ期和無淋巴結轉移患者(P＜0.05).結論 結腸癌組織中Survivin、MMP-9和VEGF的錶達水平明顯升高,在結腸癌的浸潤轉移中起到瞭重要的作用,可作為反映結腸癌進展的生物學指標.
목적 탐토Survivin、기질금속단백매-9(MMP-9)화혈관내피생장인자(VEGF)재결장암조직중적표체급기여종류진표적관계.방법 채용면역조화SP법검측60례결장암조직중Survivin、MMP-9화VEGF표체정황,병이25례정상결장조직작위대조.결과 결장암조직중Survivin、MMP-9화VEGF표체현저고우정상결장조직(P＜0.05).결장암환자중Ⅲ～Ⅳ기、림파결전이환자적Survivin、MMP-9화VEGF양성표체솔분별고우Ⅰ～Ⅱ기화무림파결전이환자(P＜0.05).결론 결장암조직중Survivin、MMP-9화VEGF적표체수평명현승고,재결장암적침윤전이중기도료중요적작용,가작위반영결장암진전적생물학지표.
Objective To investigate the expression and clinical significance of Survivin,matrix metalloproteinase(MMP-9) and vascular endothelial growth factor(VEGF) in colonic carcinoma tissue and its relationship with tumor progress.Methods The expression levels of Survivin,MMP-9 and VEGF were measured by immunohistochemistry in the resected specimens from 60 patients with colonic carcinoma and 25 controls.Results The positive rates of Survivin,MMP-9 and VEGF were significantly higher in the coIonic carcinoma patients than those in 'controls (P ＜ 0.05).The positive rates of Survivin,MMP-9 and VEGF in Ⅲ - Ⅳ stage were significantly higher than those of patients in Ⅰ - Ⅱ stage tumor ( P ＜ 0.05 ).The positive rates of Survivin,MMP-9 and VEGF in lymph node metastasis tumor were significantly higher than those of patients in non metastasis tumor (P ＜ 0.05).Conclusions Survivin,MMP-9 and VEGF expression in colonic carcinoma increases markedly and play an important role in the progression of colonic carcinoma.
