CAJ | 학술논문

用直链淀粉-三(3，5-二甲基苯基氨基甲酸酯)手性固定相，在正相条件下首次拆分了6种咔唑羧酸衍生物对映异构体。考察了流动相中不同的酸性添加剂、不同的正丙醇浓度对样品保留和拆分的影响。
용직련정분-삼(3，5-이갑기분기안기갑산지)수성고정상，재정상조건하수차탁분료6충잡서최산연생물대영이구체。고찰료류동상중불동적산성첨가제、불동적정병순농도대양품보류화탁분적영향。
Six pairs of enantiomeric compounds of carbazole derivatives were separated by high performance liquid chromatography using an amylosetris (3,5-dimethylphenylcarbamate) chiral column made in our laboratory. The mob I le phases were mixtrues of different content ofn-hexane, n-propanol and a little amount of acidic additives. It was found that the stronger the acid added, the better the separation. All the enantiomers were baseline separated with a mobile phase comtaining 1% trifluoroacetic acid and 5% n-propanol. The effect of sam ple structure on the retention factor was discussed. When the carboxylic chain of the sample became longer, the retention factor became smaller. When the sample was halogenated, the retention factor increased along with the increasing of the molecular weight of the samples.