CAJ | 학술논문

学术背景:红外光谱技术在疾病诊断和病理分析方面具有潜在的重要应用价值,并可为治疗提供准确的参考信息.目的:分析冠状动脉粥样硬化性心脏病(简称冠心病)患者内关穴红外辐射光谱中的特异性病理信息.设计:病例一对照观察.单位:上海中医药大学附属龙华医院.对象:检测于2003-04/2005-04进行,其中50例冠心病患者来自龙华医院心内科门诊,男21例,女29例;平均年龄58.1岁;非47例冠心病正常人由广告招募,男25例,女22例;平均年龄50.6岁.受试者均自愿参加检测.方法:采用中国科学院上海技术物理研究所制造的高灵敏度PHE201体表红外光谱仪,对50例冠心病患者内关穴作红外辐射光谱检测,并以47例健康成年人为对照进行比较分析.检测内关穴1.5～16 μ m波长范围内的红外辐射光谱,扫描间隔为0.2 μm,共检测73个波长. 主要观察指标:冠心病患者和正常人内关穴不同波长处的红外辐射强度.结果:在检测的73个波长中,左内关穴23个、右内关穴32个波长处的红外辐射强度,冠心病患者与正常人间存在显著差异(P<0.05-0.001).其中与能量代谢有关的2.0～2.5 μ m 波长处的红外辐射强度冠心病患者明显低于正常人(P<0.05～005).冠心病患者两侧内关穴红外辐射强度有显著差异的波长数明显多于正常人(P<0.001).结论:①冠心病患者内关穴红外辐射光谱中存在特异性病理信息.②冠心病患者内关穴区的能量代谢和气血功能活动低下.
학술배경:홍외광보기술재질병진단화병리분석방면구유잠재적중요응용개치,병가위치료제공준학적삼고신식.목적:분석관상동맥죽양경화성심장병(간칭관심병)환자내관혈홍외복사광보중적특이성병리신식.설계:병례일대조관찰.단위:상해중의약대학부속룡화의원.대상:검측우2003-04/2005-04진행,기중50례관심병환자래자룡화의원심내과문진,남21례,녀29례;평균년령58.1세;비47례관심병정상인유엄고초모,남25례,녀22례;평균년령50.6세.수시자균자원삼가검측.방법:채용중국과학원상해기술물리연구소제조적고령민도PHE201체표홍외광보의,대50례관심병환자내관혈작홍외복사광보검측,병이47례건강성년인위대조진행비교분석.검측내관혈1.5～16 μ m파장범위내적홍외복사광보,소묘간격위0.2 μm,공검측73개파장. 주요관찰지표:관심병환자화정상인내관혈불동파장처적홍외복사강 도.결과:재검측적73개파장중,좌내관혈23개、우내관혈32개파장 처적홍외복사강도,관심병환자여정상인간존재현저차이(P<0.05-0.001).기중여능량대사유관적2.0～2.5 μ m 파장처적홍외복사강도관심병환자명현저우정상인(P<0.05～005).관심병환자량측내관혈홍외복사강도유현저차이적파장수명현다우정상인(P<0.001).결론:①관심병환자내관혈홍외복사광보중존재특이성병리신식.②관심병환자내관혈구적능량대사화기혈공능활동저하.
BACKGROUND: Infrared spectrum technology has potential and important value of application in diagnosing disease and analyzing pathology, as well as providing references for proper treatment. OBJECTIVE: To analyze the distinctive pathological information in the spectrums of infrared radiation at Neiguan (PC 6) acupoint of patients with coronary atherosclerotic heart disease (CAHD). DESIGN: Case-control study.SETFING: Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine. PARTICIPANTS: The study was conducted from April 2003 to April 2005 in patients with CAHD from Out-Patient Clinic in Longhua Hospital (21 males and 29 females, averagely 58.1 years). Forty-seven healthy volunteers were all from advertisement (25 males and 22 females, averagely 50.6 years). All the subjects were voluntary. METHODS: PHE201, a high-sensitive infrared spectrum detective device (Shanghai Institute of Technical Physics of Chinese Academy of Sciences, China) was applied to detect the spectrums of infrared radiation at Neiguan in 50 patients with CAHD and 47 healthy adults were selected as control for comparison. The scanning range was from 1.5μ m to 16μ m,73 detected wavelength spots were scanned at Neiguan of all the subjects, and the scanning spacing was 0.2μ m. MAIN OUTCOME MEASURES: Intensity of infrared radiation at Neiguan between CAHD patients and normal controls at different wavelengths. RESULTS: The intensities of infrared radiation of CAHD patients were significantly different from that of the healthy volunteers at 32 spots of the right Neiguan as well as at 23 spots of the left Neiguan among the 73 detected wavelength spots(P < 0.05-0.001). At 2-2.5μ m wavelength spots that were related to the energy metabolism, the intensities of infrared radiation of CAHD patients were significantly lower than the healthy volunteers (P < 0.05-0.005). Concerning the difference in intensities of infrared radiation between the left and the right Neiguan, the CAHD patients had more wavelength spots than healthy volunteers did (P < 0.001). CONCLUSION: ①Distinctive pathological information exists in the infrared spectrums at Neiguan in CAHD patients. ②CAHD patients have hypo-activities of energy metabolism and hypo-function ofqi and blood in the area of Neiguan.