CAJ | 학술논문

以截短侧耳素为起始原料,首先与二甲基半胱胺盐酸盐进行相转移催化反应,然后与氨基保护的缬氨酸进行酰胺化反应,最后脱掉保护基,用盐酸处理,即得到盐酸沃尼妙林,收率54.9%,产物经红外光谱和核磁氢谱进行了确证.本方法更加适合于工业化生产.
이절단측이소위기시원료,수선여이갑기반광알염산염진행상전이최화반응,연후여안기보호적힐안산진행선알화반응,최후탈도보호기,용염산처리,즉득도염산옥니묘림,수솔54.9%,산물경홍외광보화핵자경보진행료학증.본방법경가괄합우공업화생산.
Using pleuromutilin as a starting material,dimethyl cysteamine hydrochloride as a phase transfer catalyst,through amino-protected valine reaction,and after removing the protection base with hydrochloric acid,valnemulin hydrochloride is prepared with a yield of 54.9%.The product is confirmed by IR and 1H-NMR.This synthetic route may be suitable for the industrial production.