CAJ | 학술논문

目的探讨益气药、活血药在抗衰老过程中发挥的不同作用及机制.方法通过腹腔注射D-半乳糖(D-gal)建立大鼠衰老模型,同时模型给药组按不同剂量灌饲中药.50 d后处死检测其胸腺、脾脏的重量,大脑皮层超氧化物歧化酶(SOD)、丙二醛(MDA)含量.结果与模型组相比给药各组胸腺和脾脏重量均有增加(P<0.05).与模型组相比各给药组均显著提高大脑皮层SOD活性(P<0.01),降低MDA的含量(P<0.01),但作用有差别.结论益气药、活血药在延缓衰老中发挥的作用各有侧重,合理剂量、共同使用效果最佳.
목적 탐토익기약、활혈약재항쇠로과정중발휘적불동작용급궤제.방법 통과복강주사D-반유당(D-gal)건립대서쇠로모형,동시모형급약조안불동제량관사중약.50 d후처사검측기흉선、비장적중량,대뇌피층초양화물기화매(SOD)、병이철(MDA)함량.결과 여모형조상비급약각조흉선화비장중량균유증가(P<0.05).여모형조상비각급약조균현저제고대뇌피층SOD활성(P<0.01),강저MDA적함량(P<0.01),단작용유차별.결론 익기약、활혈약재연완쇠로중발휘적작용각유측중,합리제량、공동사용효과최가.
Objective To observe the impact of the Formula Benefiting Qi and Activating Blood Circulation on playing different roles about anti-aging and to investigate its mechanisms. Methods The model groups were established by abdomen injection with D-gal. At the same time, the model dosage groups were administered with Formula Benefiting Qi and Activating Blood Circulation according to different dosage. After treatment 50 d, the weights of spleen and thymus glands were tested, and the levels of SOD and MDA of cortex were measured. Results The weights of spleens and thymus glands of rats in the dosage groups were increased compared with those in the model group (P<0.05).Compared with those of the model group, the levels of SOD were elevated more greatly (P<0.01) and the levels of MDA were decreased(P<0.01) in the dosage groups, but the function was different. Conclusions Benefiting Qi drug and Activating Blood drug plays the different role in the anti-aging aspect, using the two kinds of medicine together in a proper dosage is more potent than using only one kind.