CAJ | 학술논문

目的探讨CX3CR1-V249I、T280M与冠心病(CAD)的关联性.方法检索中英文数据库,以得到CX3CR1-V249I、T280M与CAD易感性关系的病例对照研究,采用Meta分析方法合并V249I、T280M与CAD关联的OR值,同时进行文献发表偏倚检验.结果共纳入文献6篇.对于V249I,共纳入病例1 551人,对照1 804人,I型相对于V型合并OR=0.85(95%CI=0.67～1.08,P＞0.05);对于T280M,共纳入病例1 555人,对照1 801人,M型相对于T型合并OR=0.82(95%CI=0.70～0.96,P＜0.05).结论 T280M为CAD的保护性因素,V249I与CAD的发生无关联.
목적 탐토CX3CR1-V249I、T280M여관심병(CAD)적관련성.방법 검색중영문수거고,이득도CX3CR1-V249I、T280M여CAD역감성관계적병례대조연구,채용Meta분석방법 합병V249I、T280M여CAD관련적OR치,동시진행문헌발표편의검험.결과 공납입문헌6편.대우V249I,공납입병례1 551인,대조1 804인,I형상대우V형합병OR=0.85(95%CI=0.67～1.08,P＞0.05);대우T280M,공납입병례1 555인,대조1 801인,M형상대우T형합병OR=0.82(95%CI=0.70～0.96,P＜0.05).결론 T280M위CAD적보호성인소,V249I여CAD적발생무관련.
Objective To find whether CX3CR1 V249I and T280M are associated with CAD. Methods Database in English and Chinese, including PUBMED, EMbase, were searched to get the case-control studies on the associa-tion between V249I, T280M and CAD. Results Six studies were reviewed. The pooled OR of V249I compared to wild type allele was OR =0. 85(95% CI =0. 67 ～ 1. 08,P >0. 05). The pooled OR of T280M compared to wild type allele was OR =0. 82(95% CI =0. 70 ～ 0. 96, P < 0. 05). Conclusion The T280M is a protective factor of CAD, while the V249I is not associated with CAD.