CAJ | 학술논문

背景近年来发现,脑源性神经营养因子(brain-derived neurotrophic factor,BDNF)的血清浓度与双相障碍症状关系的研究结果不一致.目的检验BDNF血清浓度与双相障碍的关系,并讨论双相障碍家族史在两者关系中的作用.方法检测了228例双相障碍患者和153名健康对照者的BDNF血清浓度,采用杨氏躁狂量表和汉密尔顿抑郁量表(17项)评估患者的躁狂或抑郁症状,将杨氏躁狂量表评分≥20分定义为躁狂发作,共计85例;将汉密尔顿抑郁量表评分≥17分定义为抑郁发作,共计14例;将杨氏躁狂量表评分<20分并且汉密尔顿抑郁量表评分<17分定义为缓解期,共计129例.结果患者组平均(标准差)BDNF血清浓度低于健康对照组[18.75 (8.98) ng/ml 比23.72 (5.60) ng/ml,t=6.09,P<0.001],且各个亚组(躁狂组、抑郁组和缓解期组)与健康对照组BDNF血清浓度的差异均有统计学意义.躁狂发作期与缓解期之间的BDNF血清浓度差异有统计学意义,其余各亚组间的差异无统计学意义.在多元线性回归模型中控制各个因素后,发现仅有杨氏躁狂量表评分与BDNF血清浓度呈正相关(标准回归系数=0.17,P=0.011).结论双相障碍患者的BDNF血清浓度低于健康对照组,BDNF血清浓度与躁狂症状存在正相关,与是否存在家族史并不相关.
배경근년래발현,뇌원성신경영양인자(brain-derived neurotrophic factor,BDNF)적혈청농도여쌍상장애증상관계적연구결과불일치.목적검험BDNF혈청농도여쌍상장애적관계,병토론쌍상장애가족사재량자관계중적작용.방법 검측료228례쌍상장애환자화153명건강대조자적BDNF혈청농도,채용양씨조광량표화한밀이돈억욱량표(17항)평고환자적조광혹억욱증상,장양씨조광량표평분≥20분정의위조광발작,공계85례;장한밀이돈억욱량표평분≥17분정의위억욱발작,공계14례;장양씨조광량표평분<20분병차한밀이돈억욱량표평분<17분정의위완해기,공계129례.결과환자조평균(표준차)BDNF혈청농도저우건강대조조[18.75 (8.98) ng/ml 비23.72 (5.60) ng/ml,t=6.09,P<0.001],차각개아조(조광조、억욱조화완해기조)여건강대조조BDNF혈청농도적차이균유통계학의의.조광발작기여완해기지간적BDNF혈청농도차이유통계학의의,기여각아조간적차이무통계학의의.재다원선성회귀모형중공제각개인소후,발현부유양씨조광량표평분여BDNF혈청농도정정상관(표준회귀계수=0.17,P=0.011).결론쌍상장애환자적BDNF혈청농도저우건강대조조,BDNF혈청농도여조광증상존재정상관,여시부존재가족사병불상관.
Background:Recent studies have reached different conclusions about the relationship of brain-derived neurotrophic factor (BDNF) and the symptoms of bipolar disorder.Objective: Examine the correlation between the serum concentration of BDNF and bipolar disorder and consider whether or not family history of bipolar disorder mediates this relationship.Methods: Serum BDNF concentrations were measured in 228 patients with bipolar disorder and 153 normal controls.Patients with bipolar disorder were assessed using the Young Mania Rating Scale (YMRS) and the Hamilton Depression Rating Scale (HAMD-17):85 with YMRS≥20 were considered manic,14 with HAMD≥17 were considered depressed,and 129 with YMRS<20 and HAMD<17 were considered euthymic.Results: The mean (SD) concentration of BDNF in bipolar patients was significantly lower than that in the control group [18.75 (8.98) ng/ml vs.23.72(5.60) ng/ml;t=6.09,P<0.001],and this difference was present persisted in all three phases of bipolar illness (manic,depressive,euthymic).Moreover,serum BDNF was significantly higher in bipolar patients in the manic phase of illness than in those in the euthymic phase of illness.After controlling for all available variables in a multivariate regression model,the only factor significantly related to higher serum BDNF levels in bipolar patients was the YMRS score (standardized regression coefficien=0.17,P=0.011).Conclusion: The serum concentration of BDNF in bipolar patients is lower than that in normal controls and is positively related to the severity of manic symptoms.It is not related to family history of bipolar disorder.