CAJ | 학술논문

神经轴突生长抑制因子受体(NgR)是髓鞘相关抑制因子Nogo-A、髓鞘相关糖蛋白(MAG)和少突胶质细胞髓鞘糖蛋白(OMgp)的共同作用途径.NgR在胶质瘤细胞黏附迁移、凋亡、神经干细胞分化及血管再生重塑等方面发挥着重要作用,有望成为针对神经胶质瘤进行分子靶向治疗的关键分子.
신경축돌생장억제인자수체(NgR)시수초상관억제인자Nogo-A、수초상관당단백(MAG)화소돌효질세포수초당단백(OMgp)적공동작용도경.NgR재효질류세포점부천이、조망、신경간세포분화급혈관재생중소등방면발휘착중요작용,유망성위침대신경효질류진행분자파향치료적관건분자.
Nogo-66 receptor(NgR) is the common way for three myelin-associated inhibitors Nogo-A,myelin associated glycoprotein(MAG) and oligodendrocyte-myelin glycoprotein(OMgp). NgR plays an impor-tant role in cell adhesion and migration, apoptosis, differentiation of neural stem ceils, angiogenesis and vascular remodeling. NgR may be a key molecule of the molecular target therapy for glioma.