中国医师进修杂志
中國醫師進脩雜誌
중국의사진수잡지
CHINESE JOURNAL OF POSTGRADUATES OF MEDICINE
2008年
29期
10-12
,共3页
谭卫民%罗时敏%葛轶群%庄思敏%罗建威
譚衛民%囉時敏%葛軼群%莊思敏%囉建威
담위민%라시민%갈질군%장사민%라건위
结直肠肿瘤%p21活化激酶1%免疫组织化学
結直腸腫瘤%p21活化激酶1%免疫組織化學
결직장종류%p21활화격매1%면역조직화학
Colorectal neoplasms%p21-activated kinase 1%Immunohiatechemistry
目的 探讨p21活化激酶1(PAK1)蛋白与大肠癌发生及生物学行为的关系.方法 采用免疫组化染色法对10例正常大肠黏膜、40例大肠绒毛状或管状腺瘤及60例大肠癌组织进行标记分析.结果 PAK1蛋白在正常大肠黏膜中的阳性率为10.0%,在大肠腺瘤伴轻、中、重度异型增生中的阳性率分别为25.0%、33.3%和33.3%,在大肠癌中的阳性率为65.0%.大肠癌PAK1蛋白阳性率高于正常大肠黏膜(P<0.01)及大肠绒毛状或管状腺瘤(P<0.01),且高于伴轻度异型增生腺瘤(P<0.01)及伴中度异型增生腺瘤(P<0.05).低分化大肠癌患者PAK1蛋白阳性率高于高分化大肠癌患者(P<0.05);而有淋巴结转移者PAKI蛋向阳性率高于无淋巴结转移者(P<0.05);Dukes分期中的C期和D期患者PAK1蛋白阳性率高于A期患者(P<0.05).结论 PAK1蛋白的表达与大肠癌的发生有一定的相关性,可作为判断大肠癌生物学行为及预后的一个有用指标.
目的 探討p21活化激酶1(PAK1)蛋白與大腸癌髮生及生物學行為的關繫.方法 採用免疫組化染色法對10例正常大腸黏膜、40例大腸絨毛狀或管狀腺瘤及60例大腸癌組織進行標記分析.結果 PAK1蛋白在正常大腸黏膜中的暘性率為10.0%,在大腸腺瘤伴輕、中、重度異型增生中的暘性率分彆為25.0%、33.3%和33.3%,在大腸癌中的暘性率為65.0%.大腸癌PAK1蛋白暘性率高于正常大腸黏膜(P<0.01)及大腸絨毛狀或管狀腺瘤(P<0.01),且高于伴輕度異型增生腺瘤(P<0.01)及伴中度異型增生腺瘤(P<0.05).低分化大腸癌患者PAK1蛋白暘性率高于高分化大腸癌患者(P<0.05);而有淋巴結轉移者PAKI蛋嚮暘性率高于無淋巴結轉移者(P<0.05);Dukes分期中的C期和D期患者PAK1蛋白暘性率高于A期患者(P<0.05).結論 PAK1蛋白的錶達與大腸癌的髮生有一定的相關性,可作為判斷大腸癌生物學行為及預後的一箇有用指標.
목적 탐토p21활화격매1(PAK1)단백여대장암발생급생물학행위적관계.방법 채용면역조화염색법대10례정상대장점막、40례대장융모상혹관상선류급60례대장암조직진행표기분석.결과 PAK1단백재정상대장점막중적양성솔위10.0%,재대장선류반경、중、중도이형증생중적양성솔분별위25.0%、33.3%화33.3%,재대장암중적양성솔위65.0%.대장암PAK1단백양성솔고우정상대장점막(P<0.01)급대장융모상혹관상선류(P<0.01),차고우반경도이형증생선류(P<0.01)급반중도이형증생선류(P<0.05).저분화대장암환자PAK1단백양성솔고우고분화대장암환자(P<0.05);이유림파결전이자PAKI단향양성솔고우무림파결전이자(P<0.05);Dukes분기중적C기화D기환자PAK1단백양성솔고우A기환자(P<0.05).결론 PAK1단백적표체여대장암적발생유일정적상관성,가작위판단대장암생물학행위급예후적일개유용지표.
Objective To investigate the role of p21-activated kinase 1 (PAK1) in colorectal mucosal carcinogenesis and the relationship between PAK1 expression and biological behavior of colorectal carcinoma. Method PAK1 was detected with immunohistochemical method in 10 normal colorectal mucosas,40 colorectal villous or tubular adenomas and 60 colorectal carcinomas. Results The positive rate for PAK1 was 10.0% in normal colorectal mucesas,and 25.0%, 33.3% and 33.3% in slight, moderate and severe dys-plastic adenomas, respectively, 65.0% was found in colorectul carcinomas. The positive rate for PAK1 in col-orectal carcinomas was higher than that in normal colorectal mucosas(P<0.01), colorectal villous or tubular adenomas(P<0.01), slight dysplastic adenomas(P<0.01) and moderate dysplastic adenomas (P<0.05).The positive rate for PAK1 of poor differentiated colorectal carcinomas was higher than that of high differentiated ones (P<0.05), and the positive rate for PAK1 of patients with lymph node metastasis was higher than that of patients without lymph node metastasis (P<0.05). In clinical stages, the positive rate for PAK1 in Dukes C and D stages patients was higher than that in Dukes A stage patients, respectively (P<0.05). Conclusion PAK1 maybe play some role in the process of carcinogenesis of colorectal mucesa, and be used as an useful marker for assessment of the biological behavior and prognosis of colorectal carcinoma.
