CAJ | 학술논문

探讨中国汉族人群血清视黄醇结合蛋白4(RBP4)水平与妊娠糖尿病的关系.收集2005年7月至2007年12月在瑞金医院妇产科行常规产前检查的孕妇195例(妊娠糖尿病组99例,正常糖耐量组96例),同时收集65例非妊娠期健康育龄期妇女作为对照组,所有受试者均排除急慢性疾病,并统一用酶联免疫法检测血清RBP4水平.与非妊娠正常对照组相比,妊娠期妇女血清RBP4水平均明显升高,妊娠糖尿病患者血清RBP4水平较正常妊娠妇女显著升高[(43.04±1.85对33.84±2.17)ms/L,P<0.01].在妊娠期妇女中,多元逐步回归分析显示,胰岛素抵抗指数(HOMA-IR)和甘油三酯是血清RBP4水平升高的独市危险因素(r2=0.165).本研究结果提示,妊娠期妇女血清RBP4水平较非妊娠妇女显著升高,而与正常孕妇相比,妊娠糖尿病患者血清RBP4水平更高;在妊娠期妇女中胰岛素抵抗和甘油三酯水平与RBP4水平显著正相关.
탐토중국한족인군혈청시황순결합단백4(RBP4)수평여임신당뇨병적관계.수집2005년7월지2007년12월재서금의원부산과행상규산전검사적잉부195례(임신당뇨병조99례,정상당내량조96례),동시수집65례비임신기건강육령기부녀작위대조조,소유수시자균배제급만성질병,병통일용매련면역법검측혈청RBP4수평.여비임신정상대조조상비,임신기부녀혈청RBP4수평균명현승고,임신당뇨병환자혈청RBP4수평교정상임신부녀현저승고[(43.04±1.85대33.84±2.17)ms/L,P<0.01].재임신기부녀중,다원축보회귀분석현시,이도소저항지수(HOMA-IR)화감유삼지시혈청RBP4수평승고적독시위험인소(r2=0.165).본연구결과제시,임신기부녀혈청RBP4수평교비임신부녀현저승고,이여정상잉부상비,임신당뇨병환자혈청RBP4수평경고;재임신기부녀중이도소저항화감유삼지수평여RBP4수평현저정상관.
To investigate the relationship between serum retinol-binding protein 4(RBP4) and gestational diabetes mellitus (GDM) in Chinese Han pregnant women.195 (23-42 years) pregnant women were recruited (July 2005 to December 2007) from the Department of Gynecology and Obstetric in Ruijin Hospital during their visiting for routine prenatal examination.99 subjects belonged to GDM group,and 96 belonged to the group with normal glucose tolerance (NGT).65 non-pregnant healthy women served as control.Serum RBP4 was measured using sandwich enzyme linked immunosorbent assay (ELISA).Pregnant women had higher level of serum RBP4 than that of non-pregnant control.The concentration of serum RBP4 was significantly increased in GDM group as compared with NGT group[(43.04±1.85 vs 33.84±2.17) rag/L,P<0.01].Multiple stepwise regression analysis showed that triglycerides and homeostasis assessment for insulin resistance (HOMA-IR) were independent variables of RBP4 (r2 =0.165) in pregnant women.The results suggest that serum RBP4 level is significantly increased in pregnant women.Women with GDM had even higher RBP4 level than that of normal pregnant women,and RBP4 levele was positively correlated with triglycerides and HOMA-IR.