CAJ | 학술논문

目的研究外照射联合131I-chTNT对荷瘤小鼠肿瘤生长的影响,并观察其在小鼠体内的分布和显像.方法建立C57小鼠Lewis瘤模型,肿瘤直径达一定大小时随机分组进行实验.测量给药后不同时间肿瘤组织及感兴趣器官的放射性,观察活体显像情况及荷瘤小鼠肿瘤生长延迟效应.结果联合外照射组肿瘤组织的放射性1、3和5 d均高于单药组,组间差异有统计学意义(P值分别为0.018、0.041和0.024),两组中正常组织的放射性差别无统计学意义(P>0.05).联合组肿瘤区核素显像比单药组强且持续时间长.肿瘤生长效应实验中单药组、外照射组、联合组的绝对延迟时间为3.1、9.1和13.1 d,标准化延迟时间为10 d,131I-chTNT对放射的增益因子为1.08.结论外照射联合131l-chTNT后可促进其在小鼠体内肿瘤区的浓聚,而对正常组织无影响.联合应用131I-chTNT町提高外照射对荷瘤小鼠的放射效应.
목적 연구외조사연합131I-chTNT대하류소서종류생장적영향,병관찰기재소서체내적분포화현상.방법 건립C57소서Lewis류모형,종류직경체일정대소시수궤분조진행실험.측량급약후불동시간종류조직급감흥취기관적방사성,관찰활체현상정황급하류소서종류생장연지효응.결과 연합외조사조종류조직적방사성1、3화5 d균고우단약조,조간차이유통계학의의(P치분별위0.018、0.041화0.024),량조중정상조직적방사성차별무통계학의의(P>0.05).연합조종류구핵소현상비단약조강차지속시간장.종류생장효응실험중단약조、외조사조、연합조적절대연지시간위3.1、9.1화13.1 d,표준화연지시간위10 d,131I-chTNT대방사적증익인자위1.08.결론 외조사연합131l-chTNT후가촉진기재소서체내종류구적농취,이대정상조직무영향.연합응용131I-chTNT정제고외조사대하류소서적방사효응.
Objective To investigate the biodistribution and scintigraphy of Lewis carcinoma of mice with 131I-chTNT combined with or without irradiation,and to study the effects on the tumor growth of mice. Methods When the tumor size in C57 mice bearing Lewis carcinoma in the right leg was big enough,the micewere randomly divided into different groups to receive different treatment.The biodistribution and scintigraphy of 131I-chTNT were observed at varous time after tail-intravenous injection in tumor-bearing mice.The effect of treatment was assessed by tumor growth delay.Results The uptake of 131I-chTNT in tumor tissue Was significantly higher in combined group than in 131I-chTNT group(P<0.05)and there were no more side effects in the combined group(P>0.05).The scintigraphy result showed higher tumor accumulation of 131I-chTNT in combined group than that in 131I-chTNT group.The absolute growth delay for irradiation group,131I-chTNT group and the combined group was 9.1.3.1 and 13.1 days,respectively.The nominal growth delay was 10 days,and the enhancement factor of 131I-chrTNT for RT was 1.08.Conclusions 131I-chTNT combined with irradiation can increase the uptake of 131I-chTNT in tumor without side effects.131I-chTNT can enhance the radiotherapeutic effect for tumor-bearing mice.