中国医药
中國醫藥
중국의약
CHINA MEDICINE
2008年
6期
338-340
,共3页
烟雾病%成年人
煙霧病%成年人
연무병%성년인
Moyamoya disease%Adult
目的 探讨成年人烟雾病进展的临床特征.方法 总结我院42例成年人烟雾病患者,其中40例患者纳入研究,33例为双侧病变,7例为单侧病变,所有患者平均随访70.2个月,1～2年采用磁共振成像、磁共振血管造影进行随访检查,发现可疑疾病进展时则行数字减影血管造影检查.根据疾病进展情况把患者分成进展组和稳定组.结果 在随访期间,40例患者中8例出现病情进展,单侧及双侧病变均可出现疾病进展,前、后循环均可累及,8例患者中7例出现与病情进展相关的再出血或缺血.单因素检验表明性别、初次发病年龄、发病表现(缺血或出血)、病变血管类型(单侧或双侧)、手术(脑颞肌贴覆术)治疗在疾病进展和稳定2组中均无统计学意义(P>0.05).结论 成年人烟雾病患者病情进展的发生率高于以往认识,进行长期随访,及早发现进展、预防再次中风、提高预后是很必要的.
目的 探討成年人煙霧病進展的臨床特徵.方法 總結我院42例成年人煙霧病患者,其中40例患者納入研究,33例為雙側病變,7例為單側病變,所有患者平均隨訪70.2箇月,1～2年採用磁共振成像、磁共振血管造影進行隨訪檢查,髮現可疑疾病進展時則行數字減影血管造影檢查.根據疾病進展情況把患者分成進展組和穩定組.結果 在隨訪期間,40例患者中8例齣現病情進展,單側及雙側病變均可齣現疾病進展,前、後循環均可纍及,8例患者中7例齣現與病情進展相關的再齣血或缺血.單因素檢驗錶明性彆、初次髮病年齡、髮病錶現(缺血或齣血)、病變血管類型(單側或雙側)、手術(腦顳肌貼覆術)治療在疾病進展和穩定2組中均無統計學意義(P>0.05).結論 成年人煙霧病患者病情進展的髮生率高于以往認識,進行長期隨訪,及早髮現進展、預防再次中風、提高預後是很必要的.
목적 탐토성년인연무병진전적림상특정.방법 총결아원42례성년인연무병환자,기중40례환자납입연구,33례위쌍측병변,7례위단측병변,소유환자평균수방70.2개월,1～2년채용자공진성상、자공진혈관조영진행수방검사,발현가의질병진전시칙행수자감영혈관조영검사.근거질병진전정황파환자분성진전조화은정조.결과 재수방기간,40례환자중8례출현병정진전,단측급쌍측병변균가출현질병진전,전、후순배균가루급,8례환자중7례출현여병정진전상관적재출혈혹결혈.단인소검험표명성별、초차발병년령、발병표현(결혈혹출혈)、병변혈관류형(단측혹쌍측)、수술(뇌섭기첩복술)치료재질병진전화은정2조중균무통계학의의(P>0.05).결론 성년인연무병환자병정진전적발생솔고우이왕인식,진행장기수방,급조발현진전、예방재차중풍、제고예후시흔필요적.
Objective To observe the clinical progression of adult moyamoya disease (MMD). Methods Forty MMD patients were enrolled. Among them, 33 patients were confirmed with typical " bilateral" moyamoya disease. The other 7 patients were suspected of "unilateral" moyamoya disease. All cases were followed up with a mean period of 70.2 months. Magnetic Resonance Imaging (MRI) and Magnetic Resonance Angiography (MRA)were repeated every 1 to 2 years, and Digital subtraction angiography (DSA) was performed when MRI and MRA showed possible disease progression. Results Disease progression occurred in 8 of 40 patients (20%) during the follow-ups. Occlusive arterial lesions progressed in both anterior and posterior brain vessels. In both bilateral and unilateral groups. 7 of 8 patients developed ischemic or hemorrhagic events. Between progression group and stable group, no significant difference was shown in terms of gender, age, onset symptoms( Ischemia or Bleeding) ,type of disease (bilateral or single-sided) and bypass surgery. Conclusion The incidence of progression of adult moyamoya disease is much higher than previously recognized, Neurological and radiological follow-ups would be essential in adult moyamoya patients for stroke prevention and better outcomes.
