中华流行病学杂志
中華流行病學雜誌
중화류행병학잡지
CHINESE JOURNAL OF EPIDEMIOLOGY
2009年
8期
845-849
,共5页
王从菊%赵景波%许加亮%向泽林%梁长威%李杰
王從菊%趙景波%許加亮%嚮澤林%樑長威%李傑
왕종국%조경파%허가량%향택림%량장위%리걸
高血压%内皮型一氧化氮合酶%Meta分析
高血壓%內皮型一氧化氮閤酶%Meta分析
고혈압%내피형일양화담합매%Meta분석
Hypertension%Endothelial nitric oxide syathase%Meta-analysis
目的 综合评价中国不同地区人群内皮型一氧化氮合酶基因G894T(Glu298Asp)多态性与原发性高血压的关系.方法 以高血压组和对照组基因型和等位基凼分布的OR值为统计最,检索相关文献;应用MIX软件对各研究结果进行一致性检验和分析,并进行数据合并,评估发表偏倚的影响.结果 共10篇文献纳入Meta分析,包括1900例原发性高血压患者和1216例对照者,10篇文献中高血压组与对照组(GT+TT)/GG基因型频率和T/G等位基因频率OR值效应量的一致性检验结果均显著(P=0.013;P=0.011),并存在发表偏倚(P=0.049;P=0.038).高血压组与对照组(GT+TT)/GG基因型频率的合并OR值(95%CI)为1.79(1.33～2.42),显著性检验Z=3.83,P<0.001.高血压组与对照组T/G等位基因频率的合并OR值(95%CI)为1.73(1.32～2.27),显著性检验Z=3.92,P<0.001.结论 中国人(汉族为主)内皮型一氧化氮合酶基因894G→T多态性与原发性高血压相关.
目的 綜閤評價中國不同地區人群內皮型一氧化氮閤酶基因G894T(Glu298Asp)多態性與原髮性高血壓的關繫.方法 以高血壓組和對照組基因型和等位基凼分佈的OR值為統計最,檢索相關文獻;應用MIX軟件對各研究結果進行一緻性檢驗和分析,併進行數據閤併,評估髮錶偏倚的影響.結果 共10篇文獻納入Meta分析,包括1900例原髮性高血壓患者和1216例對照者,10篇文獻中高血壓組與對照組(GT+TT)/GG基因型頻率和T/G等位基因頻率OR值效應量的一緻性檢驗結果均顯著(P=0.013;P=0.011),併存在髮錶偏倚(P=0.049;P=0.038).高血壓組與對照組(GT+TT)/GG基因型頻率的閤併OR值(95%CI)為1.79(1.33～2.42),顯著性檢驗Z=3.83,P<0.001.高血壓組與對照組T/G等位基因頻率的閤併OR值(95%CI)為1.73(1.32～2.27),顯著性檢驗Z=3.92,P<0.001.結論 中國人(漢族為主)內皮型一氧化氮閤酶基因894G→T多態性與原髮性高血壓相關.
목적 종합평개중국불동지구인군내피형일양화담합매기인G894T(Glu298Asp)다태성여원발성고혈압적관계.방법 이고혈압조화대조조기인형화등위기당분포적OR치위통계최,검색상관문헌;응용MIX연건대각연구결과진행일치성검험화분석,병진행수거합병,평고발표편의적영향.결과 공10편문헌납입Meta분석,포괄1900례원발성고혈압환자화1216례대조자,10편문헌중고혈압조여대조조(GT+TT)/GG기인형빈솔화T/G등위기인빈솔OR치효응량적일치성검험결과균현저(P=0.013;P=0.011),병존재발표편의(P=0.049;P=0.038).고혈압조여대조조(GT+TT)/GG기인형빈솔적합병OR치(95%CI)위1.79(1.33～2.42),현저성검험Z=3.83,P<0.001.고혈압조여대조조T/G등위기인빈솔적합병OR치(95%CI)위1.73(1.32～2.27),현저성검험Z=3.92,P<0.001.결론 중국인(한족위주)내피형일양화담합매기인894G→T다태성여원발성고혈압상관.
Objective To evaluate the relationship between G894T(Glu298Asp) polymorphism in the endothelial nitric oxide synthase (eNOS)gene and essential hypertension in Chinese population from difierent regions.Methods Odds ratios(Ors) of G894T genotype and allele distributions in essential hypertension patients against healthy controls were analyzed.All the relevant studies were screened with poor-qualified studies eliminated.Meta-analysis software MIX(Meta-analysis with interactive explanations-version 1.71),was applied for investigating and analyzing heterogeneity among individual studies and summarizing the effects across studies,and the risk of publication bias was evaluated.Results A total of 1900 cases and 1216 controls from 10 studies were included.The heterogeneity between studies Was significant(P=0.013;P=0.011) and there were substantial sources of Publication bias(P=0.049;P=0.038).The pooled OR(with 95% CI) of GT+TT vs.GG genotype was 1.79(1.33-2.42)(Z=3.83,P<0.001),and the pooled OR (with 95% CI) of T vs.G allele Was 1.73(1.32-2.27)(Z=3.92,P<0.001).Conclusion In Chinese population,mainly the Hans ethnic group,894G→T mutation in the eNOS appeared to be related to essential hypertension.
