CAJ | 학술논문

海藻是海洋生物代谢产物的主要来源之一,能产生丰富多样的生物活性物质.为了更好地利用中国南海的海藻资源,分别对采自中国湛江硇洲岛的1种绿藻基根硬毛藻Chaetomorpha basiretorsa Setchell和4种红藻刺状鱼栖苔Acantophora spicififera (Vahl) Boerg、三列凹顶藻Laurencia tristicha Tseng, Chang et Xia、紫杉状海门冬Asparagopsis taxiformis (Delile) Trevisan、鸡毛菜Pterocladia tenuis Okam进行了生物活性研究,分别对细胞毒活性(KB、Bel-7402、PC-3M、Ketr3和MCF-7)、Na~+,K~+-ATPase抑制活性以及犬血管平滑肌细胞增殖抑制活性进行了筛选,部分海藻提取物表现出一定的生理活性.
해조시해양생물대사산물적주요래원지일,능산생봉부다양적생물활성물질.위료경호지이용중국남해적해조자원,분별대채자중국담강뇨주도적1충록조기근경모조Chaetomorpha basiretorsa Setchell화4충홍조자상어서태Acantophora spicififera (Vahl) Boerg、삼렬요정조Laurencia tristicha Tseng, Chang et Xia、자삼상해문동Asparagopsis taxiformis (Delile) Trevisan、계모채Pterocladia tenuis Okam진행료생물활성연구,분별대세포독활성(KB、Bel-7402、PC-3M、Ketr3화MCF-7)、Na~+,K~+-ATPase억제활성이급견혈관평활기세포증식억제활성진행료사선,부분해조제취물표현출일정적생리활성.
Algae, as favorite sources of marine secondary metabolites, contain rich kinds of bioactive compounds. The bioactive screen of ethanol extract of five marine algae, which were collected from Naozhou Island, the South Sea of China, was designed to search for bioactive compounds. The algae include one green alga Chaetomorpha basiretorsa Setchell and four red algae Acantophora spicififera (Vahl) Boerg, Laurencia tristicha Tseng, Chang et Xia, Asparagopsis taxiformis (Delile) Trevisan and Pterocladia tenuis Okam. A standard MTT method was used for testing cytotoxicity of ethanol extracts against human cancer cell lines KB, Bel-7402, PC-3M, Ketr3 and MCF-7. The inhibitory activity of extracts against Na~+,K~+-ATPase was carried out on an enzyme mode. The inhibitory activity of extracts against dog vascular smooth muscle cell proliferation was also screened by the MTT method. Some extracts showed moderate bioactivities.