有机化学
有機化學
유궤화학
CHINESE JOURNAL OF ORGANIC CHEMISTRY
2010年
1期
107-111
,共5页
李福双%徐康平%袁寿洪%颜冬兰%刘让如%谭健兵%曾光尧%周应军%谭桂山
李福雙%徐康平%袁壽洪%顏鼕蘭%劉讓如%譚健兵%曾光堯%週應軍%譚桂山
리복쌍%서강평%원수홍%안동란%류양여%담건병%증광요%주응군%담계산
乳香%化学成分%大环二萜%抗肿瘤%isoincensoleol
乳香%化學成分%大環二萜%抗腫瘤%isoincensoleol
유향%화학성분%대배이첩%항종류%isoincensoleol
Boswellia carterii Birdwood(Frankincense)%chemical constituent%macrocyclic diterpene%anti-tumor%isoincensolol
采用硅胶柱层析,制各薄层层析等色谱方法,从乳香CO2超临界提取物中分得7个大环二萜类化合物,经波谱方法鉴定为incensole acetate(1),incensole(2),incensole oxide acetate(3),isoincensole acetate(4),incensole oxide(5),isoincensole oxide(6),isoincensolol(7),其中,化合物7为新化合物,化合物4为首次从该属植物中分离得到.采用四甲基偶氮唑蓝(MTT)法观察化合物对肿瘤细胞的抑制增殖作用.
採用硅膠柱層析,製各薄層層析等色譜方法,從乳香CO2超臨界提取物中分得7箇大環二萜類化閤物,經波譜方法鑒定為incensole acetate(1),incensole(2),incensole oxide acetate(3),isoincensole acetate(4),incensole oxide(5),isoincensole oxide(6),isoincensolol(7),其中,化閤物7為新化閤物,化閤物4為首次從該屬植物中分離得到.採用四甲基偶氮唑藍(MTT)法觀察化閤物對腫瘤細胞的抑製增殖作用.
채용규효주층석,제각박층층석등색보방법,종유향CO2초림계제취물중분득7개대배이첩류화합물,경파보방법감정위incensole acetate(1),incensole(2),incensole oxide acetate(3),isoincensole acetate(4),incensole oxide(5),isoincensole oxide(6),isoincensolol(7),기중,화합물7위신화합물,화합물4위수차종해속식물중분리득도.채용사갑기우담서람(MTT)법관찰화합물대종류세포적억제증식작용.
Seven macrocyclic diterpene compounds were isolated from Boswellia carterii Birdwood (Frankincense)and purified by silica-gel column chromatorgraphy and preparative thin-layer chromatography(TLC).Their structures were elucidated as incensole acetate(1),incensole(2),incensole oxide acetate (3),isoincensole acetate(4),incensole oxide(5),isoincensole oxide(6)and isoincensolol(7).Compound 7 was a novel compound and compound 4 was isolated from this genus for the first time.Compounds 1～7suppressing Bel-7402,Hela and SW-480 cells were investigated in vitro with cytotoxic activity.
