中国医师杂志
中國醫師雜誌
중국의사잡지
JOURNAL OF CHINESE PHYSICIAN
2010年
11期
1490-1493
,共4页
基质金属蛋白酶2/代谢%基质金属蛋白酶9/代谢%血管内皮生长因子类/代谢%乳腺肿瘤/代谢/病理学%肿瘤侵润%肿瘤转移
基質金屬蛋白酶2/代謝%基質金屬蛋白酶9/代謝%血管內皮生長因子類/代謝%乳腺腫瘤/代謝/病理學%腫瘤侵潤%腫瘤轉移
기질금속단백매2/대사%기질금속단백매9/대사%혈관내피생장인자류/대사%유선종류/대사/병이학%종류침윤%종류전이
Matrix metalloproteinase 2/ME%Matrix metalloproteinase 9/ME%Vascular endothelial growth factors/ME%Breast neoplasms/ME/PA%Neoplasm invasiveness%Neoplasm metastasis
目的 研究血管内皮细胞生长因子(VEGF),基质金属蛋白酶2、9(MMP-2、MMP-9)在乳腺癌组织中的表达以及与乳腺癌侵袭转移之间的关系.方法 应用免疫组织化学SP法检测20例乳腺纤维腺瘤和12例正常乳腺组织及38例乳腺癌组织中VEGF、MMP-2和MMP-9的表达.结果 乳腺癌组织中VEGF、MMP-2和MMP-9的高表达率(63.2%,78.95%,71.1%)高于正常乳腺组织和乳腺纤维腺瘤组织(25.0%,30.0%,33.3%,35.0%,41.7%,45.0%,P＜0.05).VEGF,MMP-2,MMP-9蛋白表达与乳腺癌患者的年龄、肿瘤大小、ER及PR无关(P＞0.05);有淋巴结转移组乳腺癌组织中VEGF、MMP-2和MMP-9的高表达率[80.0%、85.0%,85.0%]高于无淋巴结转移组(44.4%、55.6%,55.6%,P＜0.05),与组织学分级有关(P＜0.05).乳腺癌组织中三种蛋白VEGF、MMP-2和MMP-9之间的表达呈正相关(rs=0.541,0.511,0.502,P＜0.01).结论 VEGF、MMP-2和MMP-9在乳腺癌中有协同作用,促进肿瘤血管形成、细胞外基质的降解和癌细胞的侵袭转移.VEGF、MMP-2及MMP-9的高表达与乳腺癌的侵袭和转移密切相关,有可能成为判断乳腺癌侵袭和转移的有价值的指标.
目的 研究血管內皮細胞生長因子(VEGF),基質金屬蛋白酶2、9(MMP-2、MMP-9)在乳腺癌組織中的錶達以及與乳腺癌侵襲轉移之間的關繫.方法 應用免疫組織化學SP法檢測20例乳腺纖維腺瘤和12例正常乳腺組織及38例乳腺癌組織中VEGF、MMP-2和MMP-9的錶達.結果 乳腺癌組織中VEGF、MMP-2和MMP-9的高錶達率(63.2%,78.95%,71.1%)高于正常乳腺組織和乳腺纖維腺瘤組織(25.0%,30.0%,33.3%,35.0%,41.7%,45.0%,P＜0.05).VEGF,MMP-2,MMP-9蛋白錶達與乳腺癌患者的年齡、腫瘤大小、ER及PR無關(P＞0.05);有淋巴結轉移組乳腺癌組織中VEGF、MMP-2和MMP-9的高錶達率[80.0%、85.0%,85.0%]高于無淋巴結轉移組(44.4%、55.6%,55.6%,P＜0.05),與組織學分級有關(P＜0.05).乳腺癌組織中三種蛋白VEGF、MMP-2和MMP-9之間的錶達呈正相關(rs=0.541,0.511,0.502,P＜0.01).結論 VEGF、MMP-2和MMP-9在乳腺癌中有協同作用,促進腫瘤血管形成、細胞外基質的降解和癌細胞的侵襲轉移.VEGF、MMP-2及MMP-9的高錶達與乳腺癌的侵襲和轉移密切相關,有可能成為判斷乳腺癌侵襲和轉移的有價值的指標.
목적 연구혈관내피세포생장인자(VEGF),기질금속단백매2、9(MMP-2、MMP-9)재유선암조직중적표체이급여유선암침습전이지간적관계.방법 응용면역조직화학SP법검측20례유선섬유선류화12례정상유선조직급38례유선암조직중VEGF、MMP-2화MMP-9적표체.결과 유선암조직중VEGF、MMP-2화MMP-9적고표체솔(63.2%,78.95%,71.1%)고우정상유선조직화유선섬유선류조직(25.0%,30.0%,33.3%,35.0%,41.7%,45.0%,P＜0.05).VEGF,MMP-2,MMP-9단백표체여유선암환자적년령、종류대소、ER급PR무관(P＞0.05);유림파결전이조유선암조직중VEGF、MMP-2화MMP-9적고표체솔[80.0%、85.0%,85.0%]고우무림파결전이조(44.4%、55.6%,55.6%,P＜0.05),여조직학분급유관(P＜0.05).유선암조직중삼충단백VEGF、MMP-2화MMP-9지간적표체정정상관(rs=0.541,0.511,0.502,P＜0.01).결론 VEGF、MMP-2화MMP-9재유선암중유협동작용,촉진종류혈관형성、세포외기질적강해화암세포적침습전이.VEGF、MMP-2급MMP-9적고표체여유선암적침습화전이밀절상관,유가능성위판단유선암침습화전이적유개치적지표.
Objective To study the expression of VEGF, MMP-2 and MMP-9 in benign and malignant lesions of breast and their effects on breast carcinoma's invasiveness and metastasis. Methods VEGF,MMP-2 and MMP-9 expression was detected by SP method in 20 breast fibroadenoma and 12 normal breast specimens taken from non-cancerous regions adjacent to breast cancer tissue and 38 breast carcinomas. Results The expression rate of VEGF, MMP-2 and MMP-9 in breast carcinoma was remarkably higher than those in normal breast tissue and breast fibrogdenoma (63.2% vs 25.0% and 30. 0% ,78. 95% vs 33.3% and 35.0% and 71.1% vs 41.7% and 45.0% ,respectively; P ＜0.05). There was a correlation between VEGF, MMP-2 and MMP-9 expression and nodal metastasis ( P ＜0.05). High expression of VEGF, MMP-2 and MMP-9 was correlated with pathological grade ( P ＜ 0.05, respectively). The overexpression of VEGF was related with those of MMP-2 and MMP-9 in breast cancer( VEGF and MMP-2:rs =0.541, P ＜0.01 ;VEGF and M M P-9: rs = 0.11, P ＜ 0.01; MMP-2and M MP-9: rs= 0P ＜ 0.01 ). Conclusion VEGF,MMP-2 and MMP-9 overexpression is strongly related to the invasiveness and metastasis of breast carcinoma, which might be valuable in evaluating tumor invasion and metastasis.
