CAJ | 학술논문

目的研究早期乳腺癌保乳手术术中放疗的可行性,评价术后并发症、乳房美容效果及肿瘤复发事件.方法 2007年6月至2010年12月,115例患者做保乳手术,59例(研究组)做术中放疗,同期有56例(对照组)术后做全乳放疗,在术后1个月评估切口愈合状况及并发症；术后1年比较两组乳房美容效果；术后随访肿瘤复发及死亡事件.结果研究组切口愈合天数为13 ～22d,对照组为9 ～14d.研究组2例出现切口脂肪液化,16例有切口水肿,对照组未见切口脂肪液化、水肿；两组均未出现术后切口感染或血肿.术后1年乳房美容评价:研究组41例中优秀或好的有36例、一般或差的5例；对照组37例中优秀或好的有25例、一般或差的有12例(P=0.031).随访3～42个月(中位24个月),研究组局部复发2例(3.39％),其中1例(1.7％)死亡；对照组局部复发1例(1.8％),无死亡.结论早期乳腺癌保乳手术术中放疗安全可靠、美容效果好、局部控制满意.
목적 연구조기유선암보유수술술중방료적가행성,평개술후병발증、유방미용효과급종류복발사건.방법 2007년6월지2010년12월,115례환자주보유수술,59례(연구조)주술중방료,동기유56례(대조조)술후주전유방료,재술후1개월평고절구유합상황급병발증；술후1년비교량조유방미용효과；술후수방종류복발급사망사건.결과 연구조절구유합천수위13 ～22d,대조조위9 ～14d.연구조2례출현절구지방액화,16례유절구수종,대조조미견절구지방액화、수종；량조균미출현술후절구감염혹혈종.술후1년유방미용평개:연구조41례중우수혹호적유36례、일반혹차적5례；대조조37례중우수혹호적유25례、일반혹차적유12례(P=0.031).수방3～42개월(중위24개월),연구조국부복발2례(3.39％),기중1례(1.7％)사망；대조조국부복발1례(1.8％),무사망.결론 조기유선암보유수술술중방료안전가고、미용효과호、국부공제만의.
Objective To evaluate intra-operative radiotherapy after breast conservative surgery in early breast cancer patients in terms of postoperative complications,cosmetic outcome and recurrence events.Methods From June 2007 to Dec 2010,115 early breast cancer patients received breast conserving surgery.Fifty-nine patients (study group) received intra-operative radiotherapy,compared with 56 patients (control group) receiving routine postoperative radiotherapy.Postoperative complications were evaluated 1 month after surgery; cosmetic outcome was evaluated 1 year postoperatively; recurrence and death events were followed up.Results The average wound healing time was 13 -22 days in study group and 9 - 14days in control group.In the study group,2 patients developed fat deliquescence,16 patients showed wound edema while no such side effects were found in control group.No infection or hematoma were found in either group.Overall cosmetic outcome was rated 1 year post operation.In the study group (41 cases),36 patients were graded as excellent or good,5 patients were as fair or poor.Meanwhile in the control group (37 cases),wounds in 25 patients were graded as excellent or good,that in 12 patients were as fair or poor (P =0.031).After a follow-up from 3 to 42 months(median:24 months),two patients (3.39％) in study group developed local cancer relapses,one of them( 1.7％ ) died.In control group,one patient ( 1.8％ )developed local relapse,and no one died.Conclusions Intra-operative radiotherapy is safe and reliable with good cosmetic outcome.