CAJ | 학술논문

目的探讨可溶性髓样细胞表达的触发因子受体-1(sTREM-1)在类风湿性关节炎(RA)患者血清中的表达及与RA病情活动的相关性.方法 80例RA患者(病例组)中,稳定期RA患者15例,活动期RA患者65例.选取健康体检者74名作为对照组.采用酶联免疫吸附试验检测研究对象血清sTREM-1的表达水平,并探讨sTREM-1与患者病史、疼痛关节数、肿胀关节数、红细胞沉降率、高敏C反应蛋白、类风湿因子及抗环瓜氨酸肽抗体的相关关系.结果 RA患者血清中sTREM-1的表达水平高于正常对照组,差异具有统计学意义[(3.2±1.3)μg/L比(2.6±1.4) μg/L,t =2.94,P ＜0.05]；活动期RA患者血清sTREM-1的表达水平高于稳定期,差异具有统计学意义[(3.3±1.2)μg/L比(0.9±0.6)μg/L,t=4.50,P＜0.05]；出现双手关节X线损害(放射学评分达2级或2级以上)的RA患者血清sTREM-1表达水平明显高于无双手关节X线损害者[(3.7±1.1) μg/L比(2.5±1.1)μg/L,t =4.52,P＜0.01]；病例组sTREM-1的表达水平与疾病活动性评分( DAS28)具有明显的相关性(r=0.8500,P＜0.01),且与RA关节肿胀数、红细胞沉降率、类风湿因子、抗环瓜氨酸肽抗体呈正相关(r值分别为0.6412、0.8263、0.4421、0.6635,均P＜0.01).结论 RA患者血清中sTREM-1呈高表达,血清sTREM-1水平可作为反映RA病情活动的指标.
목적 탐토가용성수양세포표체적촉발인자수체-1(sTREM-1)재류풍습성관절염(RA)환자혈청중적표체급여RA병정활동적상관성.방법 80례RA환자(병례조)중,은정기RA환자15례,활동기RA환자65례.선취건강체검자74명작위대조조.채용매련면역흡부시험검측연구대상혈청sTREM-1적표체수평,병탐토sTREM-1여환자병사、동통관절수、종창관절수、홍세포침강솔、고민C반응단백、류풍습인자급항배과안산태항체적상관관계.결과 RA환자혈청중sTREM-1적표체수평고우정상대조조,차이구유통계학의의[(3.2±1.3)μg/L비(2.6±1.4) μg/L,t =2.94,P ＜0.05]；활동기RA환자혈청sTREM-1적표체수평고우은정기,차이구유통계학의의[(3.3±1.2)μg/L비(0.9±0.6)μg/L,t=4.50,P＜0.05]；출현쌍수관절X선손해(방사학평분체2급혹2급이상)적RA환자혈청sTREM-1표체수평명현고우무쌍수관절X선손해자[(3.7±1.1) μg/L비(2.5±1.1)μg/L,t =4.52,P＜0.01]；병례조sTREM-1적표체수평여질병활동성평분( DAS28)구유명현적상관성(r=0.8500,P＜0.01),차여RA관절종창수、홍세포침강솔、류풍습인자、항배과안산태항체정정상관(r치분별위0.6412、0.8263、0.4421、0.6635,균P＜0.01).결론 RA환자혈청중sTREM-1정고표체,혈청sTREM-1수평가작위반영RA병정활동적지표.
Objective To investigate the correlation of expression of soluble triggering receptor expressed on myloid cells-1 ( sTREM-1 ) in the sera with the activity of rheumatoid arthritis(RA).Methods All 80 RA patients ( 15 remissive and 65 active) and 74 normal controls were enrolled in the study.Enzyme linked immunosorbent assay (ELISA) was applied to detect sTREM-1 in the sera from RA patients and normal controls.The correlation of sTREM-1 with medical history,painful joint count,swollen joint count,erythocyte sedimentation rate,highsensitivity C-reactive protein,rheumatoid factor and anti-cyclic citmllinated peptide antibody were observed.Results The level of sTREM-1 in RA patients was higher than that in the normal ones and the difference had a statistical significance [ ( 3.2 ± 1.3 ) μg/L vs (2.6 ± 1.4 ) μg/L,r =2.94,P ＜ 0.05 ].The level of sTREM-1 in active RA patients was higher than that in the remissive ones [ ( 3.3 ± 1.2 ) μg/L vs (0.9 ± 0.6 ) μg/L,r =4.50,P ＜0.05 ].The sTREM-1 level in patients with X-ray damage of hands joint was higher than that in patients with non-X-ray damage of hand joint[ (3.7 ±1.1) μg/L vs (2.5 ± 1.1) μg/L,r =4.52,P＜0.01 ].There was a significant association between sTREM-1 level and DAS28 score,swollen joint count,erythrocyte sedimentation rate,rheumatoid factor and anti-cyclic citrullinated peptide antibody in RA patients ( r1 =0.8500,r2 =0.6412,r3 =0.8263,r4 =0.4421,r5 =0.6635,all P ＜ 0.01 ).Conclusions Level of sTREM-1 are high in sera of RA patients.Positive correlation with DAS28,the number of swollen joints,erythrocyte sedimentation rate,rheumatoid factor,anti-cyclic citrullinated peptide antibody and Serum sTREM-1 may be indicators of disease activity.