国际肿瘤学杂志
國際腫瘤學雜誌
국제종류학잡지
JOURNAL OF INTERNATIONAL ONCOLOGY
2009年
3期
166-169
,共4页
NF-κB%炎症%肿瘤形成过程
NF-κB%炎癥%腫瘤形成過程
NF-κB%염증%종류형성과정
NF-κappa B%Inflammation%Neoplastic processes
炎症与肿瘤存在相关性,但对其分子机制却知之甚少.最近研究发现,核因子κB抑制物激酶-核因子κB (IKK·NFκB)信号途径在炎症相关性肿瘤中发挥积极作用.活化IKK-NFκB信号途径主要通过上调促炎症基因的表达和下调抗凋亡蛋白的表达对肿瘤发生起作用.此外,肿瘤周围异常微环境也可激活IKK-NFκB信号途径,调节与肿瘤发生发展有关的一系列靶基因的表达,促进肿瘤发展.
炎癥與腫瘤存在相關性,但對其分子機製卻知之甚少.最近研究髮現,覈因子κB抑製物激酶-覈因子κB (IKK·NFκB)信號途徑在炎癥相關性腫瘤中髮揮積極作用.活化IKK-NFκB信號途徑主要通過上調促炎癥基因的錶達和下調抗凋亡蛋白的錶達對腫瘤髮生起作用.此外,腫瘤週圍異常微環境也可激活IKK-NFκB信號途徑,調節與腫瘤髮生髮展有關的一繫列靶基因的錶達,促進腫瘤髮展.
염증여종류존재상관성,단대기분자궤제각지지심소.최근연구발현,핵인자κB억제물격매-핵인자κB (IKK·NFκB)신호도경재염증상관성종류중발휘적겁작용.활화IKK-NFκB신호도경주요통과상조촉염증기인적표체화하조항조망단백적표체대종류발생기작용.차외,종류주위이상미배경야가격활IKK-NFκB신호도경,조절여종류발생발전유관적일계렬파기인적표체,촉진종류발전.
There have been increasing evidences supporting the relationship between inflammation and tumor,but the exact molecular mechanism correlating the two remaines nebulous. Recently,it is found that IKK- NFκB signaling pathway plays a critical role in inflammation-associated tumor. The major pro-tumorigenic func-tion of IKK-NFκB signaling pathway is to upregulate production of key pro-inflammatory cytokines and/or to in- duce the expression of genes coding for anti-apoptosis proteins. In addition, abnormal microenvironment around tumor can activate IKK-NFκB signaling pathway,whose target genes contribute to tumorigenesis. This review fo-cuses on IKKP-NFκB signaling pathway, which is a crucial mediator in inflammation - induced tumor promotion and progression, as well as an important modulator of tumor me-tastasis.
