国际医药卫生导报
國際醫藥衛生導報
국제의약위생도보
INTERNATIONAL MEDICINE & HEALTH GUIDANCE NEWS
2012年
9期
1286-1288
,共3页
内美通%促性腺激素释放激素激动剂%子宫内膜异位症%临床研究
內美通%促性腺激素釋放激素激動劑%子宮內膜異位癥%臨床研究
내미통%촉성선격소석방격소격동제%자궁내막이위증%림상연구
Gestrinone%Gonadotropin-releasing hormone agonist%Endometriosis%Clinical research
目的 研究观察内美通联合促性腺激素释放激素激动剂( GnRH-a)治疗子宫内膜异位症的临床疗效.方法 将我院收治的80例子宫内膜异位症患者随机均分为两组:观察组给予内美通联合GnRH-a治疗,对照组给予GnRH-a治疗.观察两组患者的症状、体征和盆腔超声检查等,并进行分析.结果 观察组中有36例完全治愈,3例缓解,1例复发；对照组有29例完全治愈,9例缓解,2例复发.两组比较差异有统计学意义(P＜ 0.05).服药后的毒副作用在阴道出血、ALT升高方面差异具有统计学意义(P＜0.05).观察组用药前后FSH、LH、E2均下降,各项指标差异具有统计学意义(P＜0.05)；对照组的差异无统计学意义(P＞ 0.05).结论 内美通联合GnRH-a治疗子宫内膜异位症可以有效的提高治疗效果、降低复发率和药物的不良反应,是一种有较高价值的方法.
目的 研究觀察內美通聯閤促性腺激素釋放激素激動劑( GnRH-a)治療子宮內膜異位癥的臨床療效.方法 將我院收治的80例子宮內膜異位癥患者隨機均分為兩組:觀察組給予內美通聯閤GnRH-a治療,對照組給予GnRH-a治療.觀察兩組患者的癥狀、體徵和盆腔超聲檢查等,併進行分析.結果 觀察組中有36例完全治愈,3例緩解,1例複髮；對照組有29例完全治愈,9例緩解,2例複髮.兩組比較差異有統計學意義(P＜ 0.05).服藥後的毒副作用在陰道齣血、ALT升高方麵差異具有統計學意義(P＜0.05).觀察組用藥前後FSH、LH、E2均下降,各項指標差異具有統計學意義(P＜0.05)；對照組的差異無統計學意義(P＞ 0.05).結論 內美通聯閤GnRH-a治療子宮內膜異位癥可以有效的提高治療效果、降低複髮率和藥物的不良反應,是一種有較高價值的方法.
목적 연구관찰내미통연합촉성선격소석방격소격동제( GnRH-a)치료자궁내막이위증적림상료효.방법 장아원수치적80례자궁내막이위증환자수궤균분위량조:관찰조급여내미통연합GnRH-a치료,대조조급여GnRH-a치료.관찰량조환자적증상、체정화분강초성검사등,병진행분석.결과 관찰조중유36례완전치유,3례완해,1례복발；대조조유29례완전치유,9례완해,2례복발.량조비교차이유통계학의의(P＜ 0.05).복약후적독부작용재음도출혈、ALT승고방면차이구유통계학의의(P＜0.05).관찰조용약전후FSH、LH、E2균하강,각항지표차이구유통계학의의(P＜0.05)；대조조적차이무통계학의의(P＞ 0.05).결론 내미통연합GnRH-a치료자궁내막이위증가이유효적제고치료효과、강저복발솔화약물적불량반응,시일충유교고개치적방법.
Objective To observe the clinical efficacy of gonadotropin-releasing hormone agonist ( GnRH-a ) combined with gestrinone in the treatment of endometriosis.Methods 80 patients with endometriosis were randomly assigned to receive gestrinone combined with GnRH-a ( study group ),or GnRH-a alone ( control group ).The symptoms,signs, and findings of pelvic ultrasonic examination were observed and analyzed.Results In the study group, 36 patients were cured,3 had symptom relief,and one developed relapse,whereas 29 patients were cured,9 had symptom relief,and 2 occurred relapse in the control group,with a significant difference ( P＜ 0.05 ).The rate of adverse reactions including vaginal bleeding and ALT elevation differed significantly between the two groups ( P＜ 0.05 ).As compared with the baselines,levels of FSH,LH,and E2 declined significantly in the study group ( P＜ 0.05 ) but did not change significantly in the control group ( P ＞ 0.05 ).Conclusions Gestrinone combined with GnRH-a can effectively improve the therapeutic effect and can reduce the rates of relapse rate and adverse reactions.It ias a valuable therapy.
