中华器官移植杂志
中華器官移植雜誌
중화기관이식잡지
CHINESE JOURNAL OF ORGAN TRANSPLANTATION
2000年
2期
98-99
,共2页
彭钧铮%张元芳%丁强%齐世杰%徐大生%陈惠方
彭鈞錚%張元芳%丁彊%齊世傑%徐大生%陳惠方
팽균쟁%장원방%정강%제세걸%서대생%진혜방
心脏移植%霉酚酸%雷帕霉素
心髒移植%黴酚痠%雷帕黴素
심장이식%매분산%뢰파매소
Heart transplantation%Mycophenolate mofetil%Rapamycin
目的 评价霉酚酸酯(MMF)与雷帕霉素(RAPA)合用预防及逆转大鼠心脏移植后排斥反应的作用.方法 将实验动物随机分为4组:(1)对照组;(2)单用MMF组;(3)单用RAPA组;(4)MMF与RAPA合用组.结果 单用MMF和单用RAPA组与对照组比较均显著延长移植心脏存活时间,MMF与RAPA合用组与对照组比较非常显著地延长移植心脏存活时间,并且心脏存活时间明显长于同剂量两药的单用组.结论 MMF与RAPA具有很强的协同效应,能够预防与逆转大鼠心脏移植排斥反应.
目的 評價黴酚痠酯(MMF)與雷帕黴素(RAPA)閤用預防及逆轉大鼠心髒移植後排斥反應的作用.方法 將實驗動物隨機分為4組:(1)對照組;(2)單用MMF組;(3)單用RAPA組;(4)MMF與RAPA閤用組.結果 單用MMF和單用RAPA組與對照組比較均顯著延長移植心髒存活時間,MMF與RAPA閤用組與對照組比較非常顯著地延長移植心髒存活時間,併且心髒存活時間明顯長于同劑量兩藥的單用組.結論 MMF與RAPA具有很彊的協同效應,能夠預防與逆轉大鼠心髒移植排斥反應.
목적 평개매분산지(MMF)여뢰파매소(RAPA)합용예방급역전대서심장이식후배척반응적작용.방법 장실험동물수궤분위4조:(1)대조조;(2)단용MMF조;(3)단용RAPA조;(4)MMF여RAPA합용조.결과 단용MMF화단용RAPA조여대조조비교균현저연장이식심장존활시간,MMF여RAPA합용조여대조조비교비상현저지연장이식심장존활시간,병차심장존활시간명현장우동제량량약적단용조.결론 MMF여RAPA구유흔강적협동효응,능구예방여역전대서심장이식배척반응.
Objective To evaluate the role of combined use of mycophenolate mofetil(MMF)and rapamycin(RAPA)in prevention of acute heart allograft rejection and reversal of ongoing cardiac allograft rejection in rat.Methods The rats were randomly divided into control group and MMF group.RAPA group and MMF+RAPA group.For prevention of the acute rejection.the drugs were given from day 1 to day 30 by gavage;for reversal of the ongoing acute rejection,the drugs were given from day 4 to day 34 by gavage.Results For prevention of the acute rejection and reversal of the ongoing acute rejection,subtherapeutic doses of MMF and PAPA significantly prolonged caMiac allograft survival as compared with control group.Both drugs had a synergism interaction.Conclusion Combination of MMF and RAPA with subtherapeutic doses could produce a synergistic effect in prevention of acute cardiac allograft rejection and reversal of ongoing acute cardiac allograft rejection in the rat.
