CAJ | 학술논문

目的观察地尔硫卓静脉内给药联合美托洛尔治疗主动脉夹层的临床疗效.方法宜昌市第一人民医院2005年6月至2008年1月收治的主动脉夹层患者14例(男性10例,女性4例).地尔硫卓针剂(合贝爽静脉注射液)以1～5 μe,/(kg.min)静脉泵入,同时联合使用美托洛尔(400 mg/d).观察用药后30min,60min,120min,6 h,1 d,7 d血压、心率变化情况.数据比较采用自身配对t检验.结果用药后60 min心率显著下降,比用药前下降了(21±5)次/min,总有效率达到100%,用药后30 min收缩压、舒张压明显下降.用药后6 h收缩压降至(126.2±11.1)mmHg,舒张压降至(80.3±8.1)mmHg.无明显药物副作用出现.结论地尔硫卓针剂静脉内注射联合美托洛尔治疗急性主动脉夹层安全有效.
목적 관찰지이류탁정맥내급약연합미탁락이치료주동맥협층적림상료효.방법 의창시제일인민의원2005년6월지2008년1월수치적주동맥협층환자14례(남성10례,녀성4례).지이류탁침제(합패상정맥주사액)이1～5 μe,/(kg.min)정맥빙입,동시연합사용미탁락이(400 mg/d).관찰용약후30min,60min,120min,6 h,1 d,7 d혈압、심솔변화정황.수거비교채용자신배대t검험.결과 용약후60 min심솔현저하강,비용약전하강료(21±5)차/min,총유효솔체도100%,용약후30 min수축압、서장압명현하강.용약후6 h수축압강지(126.2±11.1)mmHg,서장압강지(80.3±8.1)mmHg.무명현약물부작용출현.결론 지이류탁침제정맥내주사연합미탁락이치료급성주동맥협층안전유효.
Objective To explore the clinical therapeutic effects of intravenous infusion of dihiazem in com-bination with metoprolol for treating aortic dissection. Method From June 2005 to January 2008, fourteen patients with aortic dissection (male 8, female 4) in the First Hospital of Yichang,were treated with diltiazen 1～5 μg/(kgrate 30 min,60 min, 120 min,6 h, 1 d and 7 d after treatment were recorded. All data were analyzed using self-matching t test. Results The heart rate reduced significantly 60 min after treatment. The heart rate reduced (21±5) beats/min from the baseline. The total effective rate was 100% .The blood pressure reduced significantly 30min after treatment. The systolic pressure reduced to (126.2±11.1 ) mmHg and diastolic pressure declined to (80.3±8.1) mmHg. No severe cardiac side-effect observed. Conclusions Dihiazem in combination with meto-prolol can reduce heart rate and blood pressure markedly and safely in aortic dissection patients.