中国医药
中國醫藥
중국의약
CHINA MEDICINE
2012年
9期
1057-1059
,共3页
朱晋坤%董文%鲁玉明%周文汀%杜峰%杨静%熊宗华
硃晉坤%董文%魯玉明%週文汀%杜峰%楊靜%熊宗華
주진곤%동문%로옥명%주문정%두봉%양정%웅종화
急性心肌梗死%银杏达莫%冠状动脉再通%QT离散度
急性心肌梗死%銀杏達莫%冠狀動脈再通%QT離散度
급성심기경사%은행체막%관상동맥재통%QT리산도
Acute myocardial infarction%Ginkgo dipyridamole%Coronary reperfusion%QT dispersion
目的 观察银杏达莫注射液对急性心肌梗死(AMI)患者冠状动脉再通治疗后QT离散度(QTd)的影响,进一步探讨其临床应用价值.方法 将68例AMI成功接受溶栓或急诊PCI术患者完全随机分为银杏达莫干预组(34例)和常规治疗组(34例),分别在冠状动脉再通治疗前和再通治疗后1、5、10 d做12导联心电图描记,计算QTd.以同期体检健康者68人为正常对照组.结果 AMI患者QTd较正常对照者明显延长[ (76±8) ms比(36±5)ms,P＜0.05].2组患者冠状动脉再通治疗后各时间点QTd较再通治疗前均明显降低[常规治疗组再通治疗后1、5、10 d分别为(56±6)、(58±5)、(46±6)ms比(76±8)ms;银杏达莫干预组分别为(56±7)、(47±5)、(36±4) ms比(77±9 )ms,均P＜0.05].常规治疗组再通治疗后10 d QTd明显低于再通治疗后1、5 d(均P ＜0.05).银杏达莫干预组再通治疗后5dQTd低于再通治疗后1d,再通治疗后10 d低于再通治疗后5d(均P＜0.05).冠状动脉再通治疗后5、10 d,银杏达莫干预组QTd明显低于常规治疗组.结论 银杏达莫注射液可有效降低AMI患者冠状动脉再通治疗后的QTd,有很好的临床应用价值.
目的 觀察銀杏達莫註射液對急性心肌梗死(AMI)患者冠狀動脈再通治療後QT離散度(QTd)的影響,進一步探討其臨床應用價值.方法 將68例AMI成功接受溶栓或急診PCI術患者完全隨機分為銀杏達莫榦預組(34例)和常規治療組(34例),分彆在冠狀動脈再通治療前和再通治療後1、5、10 d做12導聯心電圖描記,計算QTd.以同期體檢健康者68人為正常對照組.結果 AMI患者QTd較正常對照者明顯延長[ (76±8) ms比(36±5)ms,P＜0.05].2組患者冠狀動脈再通治療後各時間點QTd較再通治療前均明顯降低[常規治療組再通治療後1、5、10 d分彆為(56±6)、(58±5)、(46±6)ms比(76±8)ms;銀杏達莫榦預組分彆為(56±7)、(47±5)、(36±4) ms比(77±9 )ms,均P＜0.05].常規治療組再通治療後10 d QTd明顯低于再通治療後1、5 d(均P ＜0.05).銀杏達莫榦預組再通治療後5dQTd低于再通治療後1d,再通治療後10 d低于再通治療後5d(均P＜0.05).冠狀動脈再通治療後5、10 d,銀杏達莫榦預組QTd明顯低于常規治療組.結論 銀杏達莫註射液可有效降低AMI患者冠狀動脈再通治療後的QTd,有很好的臨床應用價值.
목적 관찰은행체막주사액대급성심기경사(AMI)환자관상동맥재통치료후QT리산도(QTd)적영향,진일보탐토기림상응용개치.방법 장68례AMI성공접수용전혹급진PCI술환자완전수궤분위은행체막간예조(34례)화상규치료조(34례),분별재관상동맥재통치료전화재통치료후1、5、10 d주12도련심전도묘기,계산QTd.이동기체검건강자68인위정상대조조.결과 AMI환자QTd교정상대조자명현연장[ (76±8) ms비(36±5)ms,P＜0.05].2조환자관상동맥재통치료후각시간점QTd교재통치료전균명현강저[상규치료조재통치료후1、5、10 d분별위(56±6)、(58±5)、(46±6)ms비(76±8)ms;은행체막간예조분별위(56±7)、(47±5)、(36±4) ms비(77±9 )ms,균P＜0.05].상규치료조재통치료후10 d QTd명현저우재통치료후1、5 d(균P ＜0.05).은행체막간예조재통치료후5dQTd저우재통치료후1d,재통치료후10 d저우재통치료후5d(균P＜0.05).관상동맥재통치료후5、10 d,은행체막간예조QTd명현저우상규치료조.결론 은행체막주사액가유효강저AMI환자관상동맥재통치료후적QTd,유흔호적림상응용개치.
Objective To observe the effect of ginkgo dipyridamole injection on QT dispersion (QTd)in patients with acute myocardial infarction (AMI)after coronary reperfusion therapy.Methods Sixty-eight cases of AMI patients underwent successful thrombolysis or emergency PCI were randomly divided into ginkgo dipyridamole injection intervention group (34 cases)and coronary reperfusion therapy alone group (34 cases).QTd changes of the 2 groups were observed in acute coronary revascularization before treatment,1 day after reperfusion therapy,5days after reperfusion therapy and 10 days after reperfusion therapy.Results QTd in patients with AMI was longer than that in the normal controls [ (76±8 )ms vs (36±5 )ms,P＜0.05 ].QTd was lower in all patients after coronary reperfusion therapy compared with that before therapy (P＜0.05 );the difference was significant.QTd was significantly decreased (P＜0.05 )in ginkgo dipyridamole injection intervention group compared with 5 days after revascularization,1 day after recanalization or 10 days after revascularization.QTd was decreased significantly in ginkgo dipyridamole injection intervention group compared with reperfusion alone treatment group both 5 days after treatment and 10 days after treatment.Conclusion Ginkgo dipyridamole injection can effectively reduce QTd in patients with AMI after coronary recanalization therapy.
