CAJ | 학술논문

目的探讨C-erbB-2在结直肠癌中的表达及临床意义.方法运用免疫组织化学EnVision两步法检测171例结直肠癌中C-erbB-2的表达情况,并取15例正常结直肠组织行对照研究.结果 C-erbB-2在结直肠癌肿瘤组织中阳性率为23.4%(40/171),在正常结直肠组织中无表达,两者差异具有统计学意义(P＜0.05).结直肠癌中细胞膜C-erbB-2强阳性表达(++和+++)5例(2.92%).C-erbB-2的表达与患者性别、肿瘤部位、大小、分化程度、浸润深度、脉管内癌栓及神经侵犯等临床病理指标无明显相关性(P＞0.05).C-erbB-2阴性表达的患者5年生存率为69.5%(91/131),阳性表达患者为65.0%(26/40),两者差异无统计学意义(P＞0.05).结论在结直肠癌中,C-erbB-2表达与临床病理指标间无相关性,其在判断预后方面无重要意义.
목적 탐토C-erbB-2재결직장암중적표체급림상의의.방법 운용면역조직화학EnVision량보법검측171례결직장암중C-erbB-2적표체정황,병취15례정상결직장조직행대조연구.결과 C-erbB-2재결직장암종류조직중양성솔위23.4%(40/171),재정상결직장조직중무표체,량자차이구유통계학의의(P＜0.05).결직장암중세포막C-erbB-2강양성표체(++화+++)5례(2.92%).C-erbB-2적표체여환자성별、종류부위、대소、분화정도、침윤심도、맥관내암전급신경침범등림상병리지표무명현상관성(P＞0.05).C-erbB-2음성표체적환자5년생존솔위69.5%(91/131),양성표체환자위65.0%(26/40),량자차이무통계학의의(P＞0.05).결론 재결직장암중,C-erbB-2표체여림상병리지표간무상관성,기재판단예후방면무중요의의.
Objective To investigate the expression of oncogene C-erbB-2 and its significance in colorectal carcinoma. Methods Immunohistological EnVision staining was used to detect the expression of C-erbB-2 in 171 colorectal carcinoma, and 15 normal colorectal tissues were taken as controls. Results The positive percentages of C-erbB-2 in colorectal carcinoma and normal colorectal tissues were 23.4 % (40/171)and 0, which was significantly different (P ＜0.05). Only 5 samples showed strong positive expression (++ and +++) on epicyte, no relationship was found between C-erbB-2 expression and patients' gender, tumor differentiation, tumor stage, vascular and lymph node involvement, etc(P ＞0.05). The five year survival rate were 69.5 % (91/131) and 65.0 % (26/40) of C-erbB-2 negative and positive expression, the difference was not statistical (P ＞0.05). Conclusion There was on significant association between C-erbB-2 expression and clinicopathologic characteristics of colorectal carcinoma. C-erbB-2 did not present prognostic value in colorectal carcinoma.