CAJ | 학술논문

目的探讨人乳腺癌中Her2阳性表达与β连环蛋白(β-catenin)及上皮性钙粘索(E-cadherin)异常表达间的关系及意义.方法应用免疫组织化学方法检测147例乳腺癌中Her2、β-catenin和E-cadherin表达情况,同时检测19例癌旁正常乳腺和17例乳腺良性病变中β-catenin和E-cadherin的表达作为对照.结果在乳腺癌组织中,Her2阳性表达与腋窝淋巴结转移、较晚的临床分期及ER、PR阴性表达显著相关(P(0.05):β-catenin的异常表达与腋窝淋巴结转移和较高的组织学分级显著相关(P<0.01);E-eadherin的异常表达与腋窝淋巴结转移和较晚的临床分期显著相关(P<0.05);β-catenin的异常表达与E-cadherin的异常表达正相关(P<0.01);Her2的阳性表达与β-catenin的异常表达正相关(P<0.01),并且二者还协同促进了乳腺癌的腋窝淋巴结转移(P<0.01).结论在人乳腺癌组织中Her2的阳性表达与β-catenin的异常表达呈正相关性,Her2的阳性表达与Wnt/β-eatenin信号通路的异常激活之问可能存在功能上的相互联系.
목적 탐토인유선암중Her2양성표체여β련배단백(β-catenin)급상피성개점색(E-cadherin)이상표체간적관계급의의.방법 응용면역조직화학방법검측147례유선암중Her2、β-catenin화E-cadherin표체정황,동시검측19례암방정상유선화17례유선량성병변중β-catenin화E-cadherin적표체작위대조.결과 재유선암조직중,Her2양성표체여액와림파결전이、교만적림상분기급ER、PR음성표체현저상관(P(0.05):β-catenin적이상표체여액와림파결전이화교고적조직학분급현저상관(P<0.01);E-eadherin적이상표체여액와림파결전이화교만적림상분기현저상관(P<0.05);β-catenin적이상표체여E-cadherin적이상표체정상관(P<0.01);Her2적양성표체여β-catenin적이상표체정상관(P<0.01),병차이자환협동촉진료유선암적액와림파결전이(P<0.01).결론 재인유선암조직중Her2적양성표체여β-catenin적이상표체정정상관성,Her2적양성표체여Wnt/β-eatenin신호통로적이상격활지문가능존재공능상적상호련계.
Objective To investigate the relationship between positive expression of Her2 and abnormal expressions of β-catenin and E-cadherin and its implications. Methods Immunohistochemistry was used to detect the expressions of Her2, β-catenin and E-cadherin in 147 samples of human breast carcinoma. The expressions of β-catenin and E-cadherin were also detected in 19 tissues adjacent to the carcinoma and 17 benign breast lesions as controls. Results In breast carcinoma, positive Her2 expression was associated with lymph node metastasis, advanced clinical stage and negative expression of ER and PR (P<0.05). Abnormal β-catenin expression was associated with positive lymph node status and high histological grade (P<0.01). Abnormality of E-cadherin expression was related to lymph node metastasis and advanced clinical stage (P<0.05). Abnormal β-catenin expression was directly correlated with abnormal E-cadherin expression (P<0.01). Her2 positivity showed a direct correlation to abnormal β-catenin expression (P<0.01), and they cooperated in promoting axillary lymph node metastasis in human breast carcinoma (P<0.01). Conclusion A direct correlation between positive Her2 expression and abnormal β-catenin expression exists in human breast carcinoma, and positive Her2 expression may have functional interactions with abnormal activation of Wnt/β-catenin signaling pathway.