国际医药卫生导报
國際醫藥衛生導報
국제의약위생도보
INTERNATIONAL MEDICINE & HEALTH GUIDANCE NEWS
2009年
3期
63-64
,共2页
肝纤维化%Ⅲ型前胶原%IV型胶原%层粘连蛋白
肝纖維化%Ⅲ型前膠原%IV型膠原%層粘連蛋白
간섬유화%Ⅲ형전효원%IV형효원%층점련단백
Hepatic fibrosis%Type Ⅲ procollagen%Type IV collagen%Laminin
目的 探讨肝纤维化血清标志物在肝病中的诊断价值.方法 采用放射免疫分析法(RIA法)检测148例肝病患者的血清Ⅲ型前胶原、IV型胶原及层粘连蛋白的含量.结果 慢活肝、肝硬化、肝癌组的血清Ⅲ型前胶原的含量均显著升高(P<0.01),而慢迁肝、急性肝炎组升高不明显(P>0.05);血清IV型胶原及层粘连蛋白含量在慢性肝炎、肝硬化及肝癌中均有不同程度的升高(P<0.01),尤以肝硬化组升高显著.结论 Ⅲ型前胶原,IV型胶原及层粘连蛋白血清含量的联合检测可作为监测肝纤维化的发生与发展的较好指标.
目的 探討肝纖維化血清標誌物在肝病中的診斷價值.方法 採用放射免疫分析法(RIA法)檢測148例肝病患者的血清Ⅲ型前膠原、IV型膠原及層粘連蛋白的含量.結果 慢活肝、肝硬化、肝癌組的血清Ⅲ型前膠原的含量均顯著升高(P<0.01),而慢遷肝、急性肝炎組升高不明顯(P>0.05);血清IV型膠原及層粘連蛋白含量在慢性肝炎、肝硬化及肝癌中均有不同程度的升高(P<0.01),尤以肝硬化組升高顯著.結論 Ⅲ型前膠原,IV型膠原及層粘連蛋白血清含量的聯閤檢測可作為鑑測肝纖維化的髮生與髮展的較好指標.
목적 탐토간섬유화혈청표지물재간병중적진단개치.방법 채용방사면역분석법(RIA법)검측148례간병환자적혈청Ⅲ형전효원、IV형효원급층점련단백적함량.결과 만활간、간경화、간암조적혈청Ⅲ형전효원적함량균현저승고(P<0.01),이만천간、급성간염조승고불명현(P>0.05);혈청IV형효원급층점련단백함량재만성간염、간경화급간암중균유불동정도적승고(P<0.01),우이간경화조승고현저.결론 Ⅲ형전효원,IV형효원급층점련단백혈청함량적연합검측가작위감측간섬유화적발생여발전적교호지표.
Objective To study the diagnostic value of serum marker for hepatic fibrosis in patients with hepatic diseases,Methods The serum levels of PC Ⅲ,IV-C and LN of 148 patients with various liver diseases were detected by RIA method.Results The serum concertration of PC Ⅲ in patients with CAH,LC,HCC was significantly higher than that in normal control(P<O.01),which was no significantly difference in patients with CPH,AH(P> 0.05).The serum levels of IV.C and LN were significantly elevated in patients with CPH,CAH,LC and HCC (P<O.O1),and the level of LC was the highest level.Conclusion Combined with measuring the serum levels of PC Ⅲ,IV*C and LN can be used as a good index for monitoring of hepatic fibrosis.
