中国基层医药
中國基層醫藥
중국기층의약
CHINESE JOURNAL OF PRIMARY MEDICINE AND PHARMACY
2009年
10期
1739-1740
,共2页
JNK丝裂原活化蛋白激酶类%多药耐药相关蛋白质类%结直肠肿瘤
JNK絲裂原活化蛋白激酶類%多藥耐藥相關蛋白質類%結直腸腫瘤
JNK사렬원활화단백격매류%다약내약상관단백질류%결직장종류
JNK mitogen-activated protein kinases%Multidrug resistance-associated proteins%Colorectal neoplasms
目的 研究磷酸化c-jun氨基末端激酶(JNK)与多药耐药相关蛋白1(MRP1)在结直肠癌组织中的表达及JNK在结直肠癌耐药中的可能机制.方法 通过免疫组织化学方法研究72例结直肠癌和40例正常大肠组织中JNK和MRP1蛋白表达及其关系.结果 JNK和MRP1蛋白在结直肠癌组织中的阳性表达率分别为47.22%和51.39%,均明显高于在正常大肠组织中的表达.JNK蛋白阳性表达与结直肠癌患者的性别、年龄、肿瘤大小、部位均无明显相关性(P>0.05),而与肿瘤分化、淋巴结转移、远处转移及Dukes分期显著相关(P<0.05).MRP1蛋白阳性表达与结直肠癌患者的性别、年龄、肿瘤大小、部位及肿瘤分化均无明显相关性(P>0.05),而与淋巴结转移、远处转移及Dukes分期显著相关(P<0.05).结论 JNK高表达与结直肠癌的发生及其恶性生物学行为相关,其可能通过上调MRP1的表达参与大肠癌化疗耐药的形成.
目的 研究燐痠化c-jun氨基末耑激酶(JNK)與多藥耐藥相關蛋白1(MRP1)在結直腸癌組織中的錶達及JNK在結直腸癌耐藥中的可能機製.方法 通過免疫組織化學方法研究72例結直腸癌和40例正常大腸組織中JNK和MRP1蛋白錶達及其關繫.結果 JNK和MRP1蛋白在結直腸癌組織中的暘性錶達率分彆為47.22%和51.39%,均明顯高于在正常大腸組織中的錶達.JNK蛋白暘性錶達與結直腸癌患者的性彆、年齡、腫瘤大小、部位均無明顯相關性(P>0.05),而與腫瘤分化、淋巴結轉移、遠處轉移及Dukes分期顯著相關(P<0.05).MRP1蛋白暘性錶達與結直腸癌患者的性彆、年齡、腫瘤大小、部位及腫瘤分化均無明顯相關性(P>0.05),而與淋巴結轉移、遠處轉移及Dukes分期顯著相關(P<0.05).結論 JNK高錶達與結直腸癌的髮生及其噁性生物學行為相關,其可能通過上調MRP1的錶達參與大腸癌化療耐藥的形成.
목적 연구린산화c-jun안기말단격매(JNK)여다약내약상관단백1(MRP1)재결직장암조직중적표체급JNK재결직장암내약중적가능궤제.방법 통과면역조직화학방법연구72례결직장암화40례정상대장조직중JNK화MRP1단백표체급기관계.결과 JNK화MRP1단백재결직장암조직중적양성표체솔분별위47.22%화51.39%,균명현고우재정상대장조직중적표체.JNK단백양성표체여결직장암환자적성별、년령、종류대소、부위균무명현상관성(P>0.05),이여종류분화、림파결전이、원처전이급Dukes분기현저상관(P<0.05).MRP1단백양성표체여결직장암환자적성별、년령、종류대소、부위급종류분화균무명현상관성(P>0.05),이여림파결전이、원처전이급Dukes분기현저상관(P<0.05).결론 JNK고표체여결직장암적발생급기악성생물학행위상관,기가능통과상조MRP1적표체삼여대장암화료내약적형성.
Objective To investigate the chnicopathogenical significance of c-jun N-terminal kinase(JNK) and multidrug resistance associated protein 1 (MRP1) expression in colorectal cancer. Methods The expression of JNK and MRP1 was detected in a tissue microarray containing 72 spots of colorectal cancer tissue and 40 spots of nor-mal colorectal tissue by immunohistochemisty. Results The positive expression rate of JNK and MRP1 expression was 47.22% and 51.39% respectively in colorectal cancer,significantly higher than that in normal colon tissue. JNK protein expression was not closely related to gender, age, tumor size and location (P>0.05), but closely related to tumor differentiation,lymph node metastasis,distsnt metastasis and Dukes staging (P<0.05). MRP1 protein expres-sion was not closely related to gender,age,tumor size,location and tumor differentiation(P> 0.05), but closely relat-ed to lymph node metastasis, distant metastasis, Dukes staging (P<0.05). Conclusions The JNK expression in cancer is corrlated with maligant biological behavior and may be involved in the chemotherapeutic resistance by upreg-ulating the expression of MRP1.
