CAJ | 학술논문

目的了解抗突变型瓜氨酸波形蛋白(MCV)抗体、葡萄糖-6-磷酸异构酶(GPI)、抗环瓜氨酸多肽(CCP)抗体检测在类风湿关节炎(RA)诊断中的价值.方法检测109例RA患者,24例其他风湿病患者及19名健康对照血清中抗MCV抗体、GPI和抗CCP抗体,比较3种抗体单独或联合检测对诊断RA的敏感性和特异性.结果 RA组抗MCV抗体和GPI阳性率及平均浓度显著高于其他风湿病组及健康对照组(P<0.05).抗CCP抗体与GPI阳性率在RA患者中的差异有统计学意义.抗MCV抗体对RA敏感性最高(99.1%);抗CCP抗体对RA特异性最高(90.7%);联合检测以MCV+CCP、MCV+GPI以及MCV+CCP+GPI特异件最高(均为98.1%).结论单独或联合检测抗MCV抗体、抗CCP抗体和GPI,有助于提高RA诊断的敏感性和特异性.
목적 료해항돌변형과안산파형단백(MCV)항체、포도당-6-린산이구매(GPI)、항배과안산다태(CCP)항체검측재류풍습관절염(RA)진단중적개치.방법 검측109례RA환자,24례기타풍습병환자급19명건강대조혈청중항MCV항체、GPI화항CCP항체,비교3충항체단독혹연합검측대진단RA적민감성화특이성.결과 RA조항MCV항체화GPI양성솔급평균농도현저고우기타풍습병조급건강대조조(P<0.05).항CCP항체여GPI양성솔재RA환자중적차이유통계학의의.항MCV항체대RA민감성최고(99.1%);항CCP항체대RA특이성최고(90.7%);연합검측이MCV+CCP、MCV+GPI이급MCV+CCP+GPI특이건최고(균위98.1%).결론 단독혹연합검측항MCV항체、항CCP항체화GPI,유조우제고RA진단적민감성화특이성.
Objeictivie To investigate the diagnostic value of anti-mutated citrullinated vimentin (anti-MCV) antibody, anti-cyclic citrullinated peptide (anti-CCP) antibodies and glucose-6-phospha-teisomerase (GP1) for rheumatoid arthritis (RA). Methods Anti-MCV antibody, GPI and anti-CCP antibody were detected in serum samples of 109 RA patients, 24 non-RA rheumatic diseases patients and 19 healthy blood donors. The sensitivity and specificity of these parameters for the diagnosis of RA were analyzed. Results Both the positive rate and average cut off concentration of anti-MCV and GPI in RA were higher than those of non-RA rheumatic diseases or healthy controls (P<0.05). A significant difference was found between anti-MCV and GPI in RA patients. The most sensitive and specific parameter in RA was anti-MCV (99.1%) and anti-CCP (90.7%) respectively, but, when anti-MCV combined with anti-CCP, or GPI or anti-CCP and GPI, the specificity could be up to 98.1%. Coniclusions Anti-MCV, anti-CCP and GPI alone or in combination may be valuable parameters for the diagnosis of RA.