北京中医药大学学报
北京中醫藥大學學報
북경중의약대학학보
JOURNAL OF BEIJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
2009年
11期
786-789
,共4页
黄俊山%张作丹%林坚%李璟怡%林求诚%郑兴敏%张维波
黃俊山%張作丹%林堅%李璟怡%林求誠%鄭興敏%張維波
황준산%장작단%림견%리경이%림구성%정흥민%장유파
血管性痴呆%软脉灵口服液%临床观察
血管性癡呆%軟脈靈口服液%臨床觀察
혈관성치태%연맥령구복액%림상관찰
vascular dementia%Ruanmailing Oral Solution%clinical observation
目的 探讨软脉灵口服液治疗血管性痴呆(VaD)患者的临床疗效及对血管性痴呆患者超氧化物歧化酶(SOD)、血管内皮生长因子(VEGF)、雌二醇(E_2)、睾酮(T)水平的影响.方法 将60例VaD患者随机分为软脉灵口服液组(治疗组)及盐酸多奈哌齐治疗组(对照组).采用单盲给药法,治疗组口服软脉灵口服液,每次1支(10 mL),每日3次,1个月为1疗程,连服3个疗程.对照组口服盐酸多奈哌齐(思博海),每次1片(5 mg),每日1次临睡前服用,疗程同治疗组.健康老年体检者(正常对照组)30例.检测SOD、 VEGF、E_2、T.并观察各组患者治疗前后简易精神状态量表(MMSE)和日常生活量表 (ADL)、中医症状积分等的变化.结果 软脉灵口服液能显著提高VaD患者血浆SOD、VEGF水平(P＜0.05),提高女VaD患者E2值、男VaD患者T值及降低男VaD患者E_2值、E_2/T值(P＜0.05或 P＜0.01),提高MMSE积分,降低ADL积分,改善临床症状.结论 软脉灵口服液可有效防治血管性痴呆.
目的 探討軟脈靈口服液治療血管性癡呆(VaD)患者的臨床療效及對血管性癡呆患者超氧化物歧化酶(SOD)、血管內皮生長因子(VEGF)、雌二醇(E_2)、睪酮(T)水平的影響.方法 將60例VaD患者隨機分為軟脈靈口服液組(治療組)及鹽痠多奈哌齊治療組(對照組).採用單盲給藥法,治療組口服軟脈靈口服液,每次1支(10 mL),每日3次,1箇月為1療程,連服3箇療程.對照組口服鹽痠多奈哌齊(思博海),每次1片(5 mg),每日1次臨睡前服用,療程同治療組.健康老年體檢者(正常對照組)30例.檢測SOD、 VEGF、E_2、T.併觀察各組患者治療前後簡易精神狀態量錶(MMSE)和日常生活量錶 (ADL)、中醫癥狀積分等的變化.結果 軟脈靈口服液能顯著提高VaD患者血漿SOD、VEGF水平(P＜0.05),提高女VaD患者E2值、男VaD患者T值及降低男VaD患者E_2值、E_2/T值(P＜0.05或 P＜0.01),提高MMSE積分,降低ADL積分,改善臨床癥狀.結論 軟脈靈口服液可有效防治血管性癡呆.
목적 탐토연맥령구복액치료혈관성치태(VaD)환자적림상료효급대혈관성치태환자초양화물기화매(SOD)、혈관내피생장인자(VEGF)、자이순(E_2)、고동(T)수평적영향.방법 장60례VaD환자수궤분위연맥령구복액조(치료조)급염산다내고제치료조(대조조).채용단맹급약법,치료조구복연맥령구복액,매차1지(10 mL),매일3차,1개월위1료정,련복3개료정.대조조구복염산다내고제(사박해),매차1편(5 mg),매일1차림수전복용,료정동치료조.건강노년체검자(정상대조조)30례.검측SOD、 VEGF、E_2、T.병관찰각조환자치료전후간역정신상태량표(MMSE)화일상생활량표 (ADL)、중의증상적분등적변화.결과 연맥령구복액능현저제고VaD환자혈장SOD、VEGF수평(P＜0.05),제고녀VaD환자E2치、남VaD환자T치급강저남VaD환자E_2치、E_2/T치(P＜0.05혹 P＜0.01),제고MMSE적분,강저ADL적분,개선림상증상.결론 연맥령구복액가유효방치혈관성치태.
Objective To investigate the curative effect of Ruanmailing Oral Solution on vascular dementia and its influences on the levels of superoxide dismutase (SOD), vascular endothelial growth factor (VEGF), estradiol (E_2) and testosterone (T) in the patients with vascular dementia (VaD).Methods All patents (n=60) were randomly divided into Ruanmailing Oral Solution group (treatment group) and Sibohai Tablets group (donepezil hydrochloside, control group). The treatment group was given Ruanmailing Oral Solution thrice daily and one piece (10 mL) each time for 3 treatment courses (a course was for one month) by applying the single blind method. The control group was given Sibohai Tablets once daily and one table (5 mg) each time at sleeping time with the same course as the treatment group. The normal control group included 30 health old persons. The levels of SOD, VEGF, E_2 and T were detected, and the integral changes of the Mini-Mental Status Examination (MMSE), Activities of Daily Life (ADL) and TCM symptoms were observed.Results Ruanmailing Oral Solution increased significantly the levels of SOD and VEGF (P<0.05), E_2 value in woman patients and T value in man patients, and decreased E_2 value and E_2/T value in man patients (P<0.05 or P<0.01). The integral of MMSE was increased and ADL integral was decreased. The clinical symptoms were relieved.Conclusion Ruanmailing Oral Solution can be used to prevent and cure VaD effectively.
