CAJ | 학술논문

背景:有研究表明番茄红素作为一种抗氧化物质能够减低患慢性疾病的风险.目的:建立去卵巢骨质疏松大鼠模型,通过给去卵巢大鼠灌服不同剂量的番茄红素,观察其对实验性骨质疏松的保护作用.方法:切除6 月龄SPF 级雌性Wistar 未生育大鼠双侧卵巢1 周,建立去卵巢骨质疏松大鼠模型,分别给予苯甲酸雌二醇,番茄红素10 mg,20 mg 进行干预.结果与结论:各组给药12 周后,番茄红素高低剂量组与卵巢切除组比较子宫质量,血清中的钙、磷含量,骨小梁面积百分比,骨小梁数目增加,血清中超氧化物歧化酶活性,骨密度和骨生物学性能均明显增高(P < 0.05);血清中碱性磷酸酶,尿中脱氧吡啶啉,丙二醛,骨小梁分离度和破骨细胞数均减少(P < 0.05).结果证实,番茄红素能明显缓解去卵巢引起的子宫萎缩,清除体内的自由基,改善去卵巢大鼠的氧化应激状态,减少骨吸收增加骨形成.
배경:유연구표명번가홍소작위일충항양화물질능구감저환만성질병적풍험.목적:건립거란소골질소송대서모형,통과급거란소대서관복불동제량적번가홍소,관찰기대실험성골질소송적보호작용.방법:절제6 월령SPF 급자성Wistar 미생육대서쌍측란소1 주,건립거란소골질소송대서모형,분별급여분갑산자이순,번가홍소10 mg,20 mg 진행간예.결과여결론:각조급약12 주후,번가홍소고저제량조여란소절제조비교자궁질량,혈청중적개、린함량,골소량면적백분비,골소량수목증가,혈청중초양화물기화매활성,골밀도화골생물학성능균명현증고(P < 0.05);혈청중감성린산매,뇨중탈양필정람,병이철,골소량분리도화파골세포수균감소(P < 0.05).결과증실,번가홍소능명현완해거란소인기적자궁위축,청제체내적자유기,개선거란소대서적양화응격상태,감소골흡수증가골형성.
BACKGROUND: A number of studies have suggested that lycopene is an antioxidant which is used to decrease the risk of age-related chronic diseases.OBJECTIVE: To establish a rat model of postmenopausal osteoporosis, and to investigate the effects of lycopene in preventing bone loss in ovatiectomized rat models of osteoporosis.METHODS: The 6-month-old female Wistar rats, SPF grade, which had never given birth, were divided into sham and ovatiectomized groups. The ovatiectomized rats were further sub-divided into four groups which were administered with corn oil orally as model group, lycopene (10 mg/kg, 20 mg/kg, daily) or treated by intraperitoneal injection with estradiol benzoate (25 mg/kg, twice).RESULTS AND CONCLUSION: After 12-week administration, as compared with the model group, the uterus weight of high-dose and low-dose lycopene groups significantly increased (P < 0.05); the Ca, P, superoxide dismutase levels, percent trabecular area,and trabecular number were obviously higher, and serum alkaline phosphatase, urine deoxypyridinoline, malondialdehyde,trabecular separation and number of osteoclasts were obviously lower in the lycopene groups than the model group (P < 0.05). The bone mass index, bone bio-mechanics and bone histomorphometry were better in the lycopene groups than the model group (P < 0.05). These findings indicate that lycopene has a definite antiosteoporotic effect on ovatiectomized rats.