CAJ | 학술논문

多聚二磷酸腺苷酸核糖聚合酶(PARP)在DNA修复中具有重要作用.在DNA同源修复障碍的肿瘤细胞中抑制PARP活性,可以引起基因组的不稳定乃至细胞死亡.基础研究证实PARP抑制剂能增强肿瘤细胞对化放疗的敏感性.在早期临床研究中,无论单一用药或联合化疗药物,PARP抑制剂都显示了在抗肿瘤治疗领域的潜力.
다취이린산선감산핵당취합매(PARP)재DNA수복중구유중요작용.재DNA동원수복장애적종류세포중억제PARP활성,가이인기기인조적불은정내지세포사망.기출연구증실PARP억제제능증강종류세포대화방료적민감성.재조기림상연구중,무론단일용약혹연합화료약물,PARP억제제도현시료재항종류치료영역적잠력.
Poly ADP-Ribose Polymerase(PARP)plays an important role in the detection and repair of DNA damage.Inhibition of the PARP activity in the homologous-recombination defective cancer cell could lead to genomic instability and ultimately cause cell death.In preclinical study PARP inhibitors have demonstrated the capacity of enhancing sensitivity of cancel cells to chemotherapy agents and radiation.PARP inhibitors also showed antitumour potential in early clinical trials as monotherapy or combined with chemotherapy.