中国基层医药
中國基層醫藥
중국기층의약
CHINESE JOURNAL OF PRIMARY MEDICINE AND PHARMACY
2011年
9期
1153-1155
,共3页
马玉东%白霞%于慧超%孙宝山%宋岩
馬玉東%白霞%于慧超%孫寶山%宋巖
마옥동%백하%우혜초%손보산%송암
高迁移率蛋白-1%超氧化物歧化酶%丙二醛%脓毒症
高遷移率蛋白-1%超氧化物歧化酶%丙二醛%膿毒癥
고천이솔단백-1%초양화물기화매%병이철%농독증
High mobility group protein box 1%Supemxide dismutase%Malondialdehyde%Sepsis
目的 探讨高迁移率蛋白B1(HMGB1)与脓毒症患者病死率的关系及其可能机制.方法 测定48例脓毒症患者血清HMGB1、超氧化物歧化酶(SOD)和丙二醛(MDA)的变化并记录患者转归.结果 发病后,死亡组和存活组患者血清HMGB1水平均逐渐上升,72 h达高峰.死亡组患者血清HMGB1水平明显高于存活组(12和24 h除外)(t=6.07、6.20、24.43,均P＜0.05).12、24、48和72 h死亡组患者血清SOD活力均明显低于存活组(t=10.24、20.61、11.67、33.33,均P＜0.05),所测时间点死亡组患者血清MDA水平均明显高于存活组(t=26.06、22.17、23.86、9.49、5.95,均P＜0.05).HMGB1水平与MDA水平成显著正相关.结论 血清HMGB1水平升高可能是脓毒症患者病死率增加的重要原因,氧化抗氧化系统失衡可能是HMGB1升高的原因之一.
目的 探討高遷移率蛋白B1(HMGB1)與膿毒癥患者病死率的關繫及其可能機製.方法 測定48例膿毒癥患者血清HMGB1、超氧化物歧化酶(SOD)和丙二醛(MDA)的變化併記錄患者轉歸.結果 髮病後,死亡組和存活組患者血清HMGB1水平均逐漸上升,72 h達高峰.死亡組患者血清HMGB1水平明顯高于存活組(12和24 h除外)(t=6.07、6.20、24.43,均P＜0.05).12、24、48和72 h死亡組患者血清SOD活力均明顯低于存活組(t=10.24、20.61、11.67、33.33,均P＜0.05),所測時間點死亡組患者血清MDA水平均明顯高于存活組(t=26.06、22.17、23.86、9.49、5.95,均P＜0.05).HMGB1水平與MDA水平成顯著正相關.結論 血清HMGB1水平升高可能是膿毒癥患者病死率增加的重要原因,氧化抗氧化繫統失衡可能是HMGB1升高的原因之一.
목적 탐토고천이솔단백B1(HMGB1)여농독증환자병사솔적관계급기가능궤제.방법 측정48례농독증환자혈청HMGB1、초양화물기화매(SOD)화병이철(MDA)적변화병기록환자전귀.결과 발병후,사망조화존활조환자혈청HMGB1수평균축점상승,72 h체고봉.사망조환자혈청HMGB1수평명현고우존활조(12화24 h제외)(t=6.07、6.20、24.43,균P＜0.05).12、24、48화72 h사망조환자혈청SOD활력균명현저우존활조(t=10.24、20.61、11.67、33.33,균P＜0.05),소측시간점사망조환자혈청MDA수평균명현고우존활조(t=26.06、22.17、23.86、9.49、5.95,균P＜0.05).HMGB1수평여MDA수평성현저정상관.결론 혈청HMGB1수평승고가능시농독증환자병사솔증가적중요원인,양화항양화계통실형가능시HMGB1승고적원인지일.
Objective To investigate the relationship and mechanism between the serum level of high mobility group box protein-1(HMGB1)and the mortality rate in patients with sepsis.Methods The serum levels of HMGB1,superoxide dismutase(SOD)and malondialdehyde(MDA)in 48 patients with sepsis were determined.The clinical outcomes in those patients were recorded and anlyzed.Results After the onset of sepsis,the serum HMGB1 levels of both death group and survival group were increased gradually and peaked at 72h after the onset of the disease.The semm HMGB1 levels of death group were much higher than those of survival group except at 24h(t=6.07,6.20,24.43,all P＜0.05).The activity of serum SOD of death group was markedly lower than that of survival group at 12h,24h,48h and 72h(t=10.24,20.61,11.67,33.33,all P＜0.05),and the level of serum MDA of death group was significantly higher than those of survival group at all time points(t=26.06,22.17,23.86,9.49,5.95,all P＜0.05).There was a significantly positive correlation between the serum HMGB1 and MDA level.Conlusioa The increase in serum HMGB1 level may be the important reasoll for the increased mortality rate in patients with sepsis;Oxidant/antioxidant imbalance may be olle reason for the increase in serum HMGB1 level.
