中国医师进修杂志
中國醫師進脩雜誌
중국의사진수잡지
CHINESE JOURNAL OF POSTGRADUATES OF MEDICINE
2009年
9期
7-10
,共4页
平滑肌瘤%栓塞,治疗性%卵巢功能试验
平滑肌瘤%栓塞,治療性%卵巢功能試驗
평활기류%전새,치료성%란소공능시험
Leiomyoma%Embolization,therapeutic%Ovarian function tests
目的 探讨子宫动脉栓塞术(UAE)治疗子宫肌瘤对年轻患者卵巢生殖内分泌功能的影响.方法 将50例年龄≤40岁的子宫肌瘤患者分为两组:<35岁组(30例)和≥35岁组(20例),实施UAE后完成24～36个月的临床症状、生殖内分泌指标以及妊娠情况的随访.结果 两组患者UAE后血清卵泡刺激素(FSH)、黄体生成素(LH)和雌二醇(E2)与术前比较差异均无统计学意义(P>0.05):两组患者UAE前后相同时间点血清FSH、LH和E2比较,差异均无统计学意义(P>0.05).两组患者月经量、月经期天数在UAE后各时间点均较UAE前减少,差异有统计学意义(P<0.05);<35岁组月经周期在UAE前后比较差异均无统计学意义(P>0.05),≥35岁组月经周期在UAE后3～6个月与UAE前比较差异有统计学意义,UAE后12个月和24～36个月与UAE前比较差异均无统计学意义(P>0.05).<35岁组中有2例出现继发性闭经;≥35岁组中有3例出现继发性闭经,1例UAE后37个月(42岁时)出现围绝经期综合征症状,血清FSH、LH水平均明显升高.妊娠情况:<35岁组术后妊娠率和分娩率分别为47%(14/30)和30%(9/30),≥35岁组分别为45%(9/20)和20%(4/20).结论 子宫肌瘤年轻患者行UAE治疗后,有短暂性继发性闭经的现象,未发现卵巢早衰或绝经情况,对卵巢生殖内分泌功能无明显影响.
目的 探討子宮動脈栓塞術(UAE)治療子宮肌瘤對年輕患者卵巢生殖內分泌功能的影響.方法 將50例年齡≤40歲的子宮肌瘤患者分為兩組:<35歲組(30例)和≥35歲組(20例),實施UAE後完成24～36箇月的臨床癥狀、生殖內分泌指標以及妊娠情況的隨訪.結果 兩組患者UAE後血清卵泡刺激素(FSH)、黃體生成素(LH)和雌二醇(E2)與術前比較差異均無統計學意義(P>0.05):兩組患者UAE前後相同時間點血清FSH、LH和E2比較,差異均無統計學意義(P>0.05).兩組患者月經量、月經期天數在UAE後各時間點均較UAE前減少,差異有統計學意義(P<0.05);<35歲組月經週期在UAE前後比較差異均無統計學意義(P>0.05),≥35歲組月經週期在UAE後3～6箇月與UAE前比較差異有統計學意義,UAE後12箇月和24～36箇月與UAE前比較差異均無統計學意義(P>0.05).<35歲組中有2例齣現繼髮性閉經;≥35歲組中有3例齣現繼髮性閉經,1例UAE後37箇月(42歲時)齣現圍絕經期綜閤徵癥狀,血清FSH、LH水平均明顯升高.妊娠情況:<35歲組術後妊娠率和分娩率分彆為47%(14/30)和30%(9/30),≥35歲組分彆為45%(9/20)和20%(4/20).結論 子宮肌瘤年輕患者行UAE治療後,有短暫性繼髮性閉經的現象,未髮現卵巢早衰或絕經情況,對卵巢生殖內分泌功能無明顯影響.
목적 탐토자궁동맥전새술(UAE)치료자궁기류대년경환자란소생식내분비공능적영향.방법 장50례년령≤40세적자궁기류환자분위량조:<35세조(30례)화≥35세조(20례),실시UAE후완성24～36개월적림상증상、생식내분비지표이급임신정황적수방.결과 량조환자UAE후혈청란포자격소(FSH)、황체생성소(LH)화자이순(E2)여술전비교차이균무통계학의의(P>0.05):량조환자UAE전후상동시간점혈청FSH、LH화E2비교,차이균무통계학의의(P>0.05).량조환자월경량、월경기천수재UAE후각시간점균교UAE전감소,차이유통계학의의(P<0.05);<35세조월경주기재UAE전후비교차이균무통계학의의(P>0.05),≥35세조월경주기재UAE후3～6개월여UAE전비교차이유통계학의의,UAE후12개월화24～36개월여UAE전비교차이균무통계학의의(P>0.05).<35세조중유2례출현계발성폐경;≥35세조중유3례출현계발성폐경,1례UAE후37개월(42세시)출현위절경기종합정증상,혈청FSH、LH수평균명현승고.임신정황:<35세조술후임신솔화분면솔분별위47%(14/30)화30%(9/30),≥35세조분별위45%(9/20)화20%(4/20).결론 자궁기류년경환자행UAE치료후,유단잠성계발성폐경적현상,미발현란소조쇠혹절경정황,대란소생식내분비공능무명현영향.
Objective To evaluate the impact of uterine artery embolization (UAE) tor uterine fibroids on ovarian function in young woman. Methods From 50 young patients with symptomatic leiomyomas managed with UAE, completed follow-up 24-36 months of clinical symptomatic, ovarian function continue and pregnancy outcome. All patients participants ranged in age from 24 to 40 years, divided into lower 35 years group (30 cases)and over 35 years group (20 cases). Results There was no significant difference in serum FSH, LH and E2 levels between two groups before UAE and 3-6, 12, 24-36 months after UAE(P > 0.05).The comparison of serum FSH, LH and E2 levels between two groups at the same time points before and after UAE were no significant difference (P> 0.05). Menstrual blood loss reduced and duration of flow shorted after UAE in two groups, the differences were significant (P < 0.05). Cycle interval in over 35 years group was longer in 3-6 months after UAE than that before UAE, the difference was significant (P <0.05). There were 2 patients occurred transient secondary amenorrhea after UAE in lower 35 years group, 3 patients occurred in over 35 years group. One patient had menopausal syndrome in 37 months after UAE, and serum FSH and LH levels were found to heighten obviously, 47% pregnancies and 30% deliveries in lower 35 years group, 45% pregnancies and 20% deliveries in over 35 years group. Conclusion Transient secondary amenorrhea would have been occurred in young patients with uterine fibroid performed UAE, no prematureo varian failure and premature menopause.
