中华行为医学与脑科学杂志
中華行為醫學與腦科學雜誌
중화행위의학여뇌과학잡지
CHINESE JOURNAL OF BEHAVIORAL MEDICINE AND BRAIN SCIENCE
2011年
4期
309-311
,共3页
消旋-3-正丁基苯酞%血管性痴呆%学习记忆能力
消鏇-3-正丁基苯酞%血管性癡呆%學習記憶能力
소선-3-정정기분태%혈관성치태%학습기억능력
3-n-butylphthalide Vascular dementia%Learning and memory abilities
目的 探讨消旋-3-正丁基苯酞(NBP)对血管性痴呆大鼠学习记忆的影响.方法 用两血管法(2VO)建立血管性痴呆(vascular dementia,VD)模型,将60只3月龄雄性Wistar大鼠随机分成VD组、假手术组和NBP组,NBP组以丁苯酞灌胃1个月,VD组和假手术组给予等量的植物油,以Morris水迷宫测试各组大鼠的学习记忆能力,HE染色观察大鼠海马区脑组织形态.结果 NBP组和假手术组和VD组的隐蔽平台逃避潜伏期[分别为(38.34±2.46)s,(14.83±3.77s),(75.74±6.33)s];原平台象限时间[分别为(26.45±4.66)s,(35.21±3.78)s,(18.67±5.39)s].与VD组相比,NBP组明显缩短隐蔽平台逃避潜伏期,增加原平台象限时间,并在HE染色中减少神经元坏死.结论 NBP能显著改善VD大鼠的学习记忆能力.
目的 探討消鏇-3-正丁基苯酞(NBP)對血管性癡呆大鼠學習記憶的影響.方法 用兩血管法(2VO)建立血管性癡呆(vascular dementia,VD)模型,將60隻3月齡雄性Wistar大鼠隨機分成VD組、假手術組和NBP組,NBP組以丁苯酞灌胃1箇月,VD組和假手術組給予等量的植物油,以Morris水迷宮測試各組大鼠的學習記憶能力,HE染色觀察大鼠海馬區腦組織形態.結果 NBP組和假手術組和VD組的隱蔽平檯逃避潛伏期[分彆為(38.34±2.46)s,(14.83±3.77s),(75.74±6.33)s];原平檯象限時間[分彆為(26.45±4.66)s,(35.21±3.78)s,(18.67±5.39)s].與VD組相比,NBP組明顯縮短隱蔽平檯逃避潛伏期,增加原平檯象限時間,併在HE染色中減少神經元壞死.結論 NBP能顯著改善VD大鼠的學習記憶能力.
목적 탐토소선-3-정정기분태(NBP)대혈관성치태대서학습기억적영향.방법 용량혈관법(2VO)건립혈관성치태(vascular dementia,VD)모형,장60지3월령웅성Wistar대서수궤분성VD조、가수술조화NBP조,NBP조이정분태관위1개월,VD조화가수술조급여등량적식물유,이Morris수미궁측시각조대서적학습기억능력,HE염색관찰대서해마구뇌조직형태.결과 NBP조화가수술조화VD조적은폐평태도피잠복기[분별위(38.34±2.46)s,(14.83±3.77s),(75.74±6.33)s];원평태상한시간[분별위(26.45±4.66)s,(35.21±3.78)s,(18.67±5.39)s].여VD조상비,NBP조명현축단은폐평태도피잠복기,증가원평태상한시간,병재HE염색중감소신경원배사.결론 NBP능현저개선VD대서적학습기억능력.
Objective To investigate the effect of 3-n-butylphthalide (NBP) on learning and memory abilities in vascular demensia (VD) rats. Methods VD model rats was established by two-vessel method. 60 3-month-old Wistar male rats were randomly divided into VD group, sham-operate group and NBP group. Rats in NBP group were given NBP 120 mg · kg-1 · d-1 ,VD and sham-operate group were given equal quality vegetable oil.Morris water maze was used to assess the learning and memory abilities in each group and HE staining was used to observe the hippocampus morphology of the rats. Results The escape latency in hidden plat test was( (38.34 ±2.46 ) s, ( 14.83 ± 3.77s ), ( 75.74 ± 6.33 ) s ) and the original platform quadrant time was ( ( 26.45 ± 4.66 ) s,(35.21 ±3.78)s, ( 18.67 ±5.39)s) in NBP group,sham-operate group and VD group respectively. Compared to VD group, NBP group had obviously decreased escape latency in hidden plat test, increased original platform quadrant time and distinctly decreased the necrosis of the neurons in HE dyeing. Conclusion NBP can improve the learning and memory deficits in VD rats.
