中国实用医刊
中國實用醫刊
중국실용의간
CENTRAL PLAINS MEDICAL JOURNAL
2010年
17期
4-5,7
,共3页
王智勇%张雪培%魏金星%赵钢勇
王智勇%張雪培%魏金星%趙鋼勇
왕지용%장설배%위금성%조강용
肾细胞癌%Smac%XIAP%免疫组织化学
腎細胞癌%Smac%XIAP%免疫組織化學
신세포암%Smac%XIAP%면역조직화학
Renal cell carcinoma%Smac%XIAP%Immunohistochemistry
目的 探讨Smac和XIAP基因在肾细胞癌组织中的表达及其临床意义.方法 采用免疫组织化学法检测95例肾癌标本不同分型、分级、分期及10例正常肾组织中Smac和XIAP的表达,分析其表达与肾癌分级、分期的关系及二者表达相关性.结果 Smac在各型肾细胞癌中随分期、分级的增加表达减低,XIAP在各型肾细胞癌中随分期、分级的增加表达增高,二者的表达呈负相关.结论 Smac和XIAP表达与肾细胞癌分期、分级关系密切,共同参与了肾癌的发生发展.
目的 探討Smac和XIAP基因在腎細胞癌組織中的錶達及其臨床意義.方法 採用免疫組織化學法檢測95例腎癌標本不同分型、分級、分期及10例正常腎組織中Smac和XIAP的錶達,分析其錶達與腎癌分級、分期的關繫及二者錶達相關性.結果 Smac在各型腎細胞癌中隨分期、分級的增加錶達減低,XIAP在各型腎細胞癌中隨分期、分級的增加錶達增高,二者的錶達呈負相關.結論 Smac和XIAP錶達與腎細胞癌分期、分級關繫密切,共同參與瞭腎癌的髮生髮展.
목적 탐토Smac화XIAP기인재신세포암조직중적표체급기림상의의.방법 채용면역조직화학법검측95례신암표본불동분형、분급、분기급10례정상신조직중Smac화XIAP적표체,분석기표체여신암분급、분기적관계급이자표체상관성.결과 Smac재각형신세포암중수분기、분급적증가표체감저,XIAP재각형신세포암중수분기、분급적증가표체증고,이자적표체정부상관.결론 Smac화XIAP표체여신세포암분기、분급관계밀절,공동삼여료신암적발생발전.
Objective To study the expression and significance of Smac and XIAP in renal cell carcinoma(RCC). Methods The expressions of Smac and XIAP were detected using SP immunohistochemical technique in 95 cases of RCC and 10 cases of normal renal tissue. Results The postitive expressions of Smac were statistically significant differences in different clinical statges. The postitive expressions of XIAP were higher in RCC related to the lower histological grade. Smac protein and XIAP protein expression had negative correlation. Conclusions It indicate that Smac and XIAP may play an important role in RCC. The expression of Smac and XIAP are statistically significant associated with tumor grade and clinical stage.
